DegronMD

Uniprot ID: Q9BVK6

Source protein: Transmembrane emp24 domain-containing protein 9

Source gene: TMED9

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6741

ASA_SCORE: 50.6889

COIL: 0.0858

CONS_SCORE: 0.5007

DSS_SCORE: 0.0137

HELIX: 0.9148

FCONS_SCORE: 1.3208

RIG_SCORE: 1.0198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T24A	TCGA-G4-6314	COAD	TCGA	MRTLLLVLW	DEG_APCC_DBOX_1	0.6028
p.T24A	DO10381	COAD	ICGC	MRTLLLVLW	DEG_APCC_DBOX_1	0.6028
p.W30L	DO229045	LICA	ICGC	MRTLLLVLW	DEG_APCC_DBOX_1	0.5904
p.V28A	DO228504	MALY	ICGC	MRTLLLVLW	DEG_APCC_DBOX_1	0.5825
p.T24S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MRTLLLVLW	DEG_APCC_DBOX_1	0.6005
p.G35E	ACH-001328	Skin Cancer	CCLE	MRTLLLVLW	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVK6	Transmembrane emp24 domain-containing protein 9	DEG_APCC_DBOX_1	22:30	MRTLLLVLW	APC,CDC20,FZR1	0.6741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons