DegronMD

Uniprot ID: P55795

Source protein: Heterogeneous nuclear ribonucleoprotein H2

Source gene: HNRNPH2

Class: LIG_APCC_ABBA_1

Location: 315:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7228

ASA_SCORE: 40.5667

COIL: 0.1303

CONS_SCORE: 0.4699

DSS_SCORE: 0.2952

HELIX: 0.0068

FCONS_SCORE: 0.8403

RIG_SCORE: 0.8086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G329S	TCGA-CD-A4MG	STAD	TCGA	MRVHIE	LIG_APCC_ABBA_1	0.0833
p.G329S	DO48009	STAD	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.0833
p.D324N	TCGA-D1-A103	UCEC	TCGA	MRVHIE	LIG_APCC_ABBA_1	0.2222
p.D324N	DO42312	UCEC	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.2222
p.D324N	SIDM00214	Colorectal Carcinoma	GDSC	MRVHIE	LIG_APCC_ABBA_1	0.2222
p.D324N	ACH-000955	Colon/Colorectal Cancer	CCLE	MRVHIE	LIG_APCC_ABBA_1	0.2222
p.D324N	SNU-407	large_intestine	COSMIC	MRVHIE	LIG_APCC_ABBA_1	0.2222
p.R326I	TCGA-DU-6392	LGG	TCGA	MRVHIE	LIG_APCC_ABBA_1	0.1667
p.R326I	DO22237	LGG	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.1667
p.G325C	DO218553	BRCA	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.1944
p.G325V	DO228978	LICA	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.1944
p.G329C	DO229028	LICA	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.0833
p.N307D	DO50976	LICA	ICGC	MRVHIE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55795	Heterogeneous nuclear ribonucleoprotein H2	LIG_APCC_ABBA_1	315:320	MRVHIE	APC,CDC20,FZR1	0.7228	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons