DegronMD

Uniprot ID: Q8TF40

Source protein: Folliculin-interacting protein 1

Source gene: FNIP1

Class: LIG_APCC_ABBA_1

Location: 832:837

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8719

ASA_SCORE: 69.5833

COIL: 0.552

CONS_SCORE: 0.3041

DSS_SCORE: 0.4607

HELIX: 0.2345

FCONS_SCORE: 1.0674

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D836N	TCGA-A5-A2K5	UCEC	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.5821
p.D842N	TCGA-AP-A051	UCEC	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.1944
p.E837K	TCGA-D1-A17Q	UCEC	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.7022
p.E845K	TCGA-DK-A6AW	BLCA	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.1111
p.E845K	TCGA-FI-A2D4	UCEC	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.1111
p.E845K	SIDM00980	Gastric Carcinoma	GDSC	MSLFDE	LIG_APCC_ABBA_1	0.1111
p.E845K	23132-87	stomach	COSMIC	MSLFDE	LIG_APCC_ABBA_1	0.1111
p.S831N	TCGA-F5-6814	READ	TCGA	MSLFDE	LIG_APCC_ABBA_1	0.3056
p.T847A	DO10276	COAD	ICGC	MSLFDE	LIG_APCC_ABBA_1	0.0556
p.C846S	DO223917	LIHC	ICGC	MSLFDE	LIG_APCC_ABBA_1	0.0833
p.P825L	DO219491	SKCM	ICGC	MSLFDE	LIG_APCC_ABBA_1	0.1389
p.D831N	DO42568	UCEC	ICGC	MSLFDE	LIG_APCC_ABBA_1	0.3056
p.N832S	ACH-000472	Head and Neck Cancer	CCLE	MSLFDE	LIG_APCC_ABBA_1	0.7069
p.N832S	HSC-2	upper_aerodigestive_tract	COSMIC	MSLFDE	LIG_APCC_ABBA_1	0.7069
p.D842H	ACH-000635	Ovarian Cancer	CCLE	MSLFDE	LIG_APCC_ABBA_1	0.1944
p.N837S	ACH-002256	Leukemia	CCLE	MSLFDE	LIG_APCC_ABBA_1	0.7069
p.N837S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MSLFDE	LIG_APCC_ABBA_1	0.7069
p.N823T	SNU-81	large_intestine	COSMIC	MSLFDE	LIG_APCC_ABBA_1	0.0833
p.S836F	23132-87	stomach	COSMIC	MSLFDE	LIG_APCC_ABBA_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF40	Folliculin-interacting protein 1	LIG_APCC_ABBA_1	832:837	MSLFDE	APC,CDC20,FZR1	0.8719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons