DegronMD

Uniprot ID: P40967

Source protein: Melanocyte protein PMEL

Source gene: PMEL

Class: DEG_SCF_FBW7_1

Location: 392:398

E3 ligase: FBXW7

DEGRON score: 0.9697

ASA_SCORE: 71.9429

COIL: 0.7139

CONS_SCORE: 0.4798

DSS_SCORE: 0.585

HELIX: 0.1909

FCONS_SCORE: 0.9902

RIG_SCORE: 0.7275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T387A	TCGA-AG-4015	READ	TCGA	MSTPEAT	DEG_SCF_FBW7_1	0.1944
p.E404D	TCGA-AX-A1CE	UCEC	TCGA	MSTPEAT	DEG_SCF_FBW7_1	0.1667
p.T394I	TCGA-AZ-6598	COAD	TCGA	MSTPEAT	DEG_SCF_FBW7_1	0.7078
p.L401M	DO223086	ESCA	ICGC	MSTPEAT	DEG_SCF_FBW7_1	0.25
p.Q405K	DO229022	LICA	ICGC	MSTPEAT	DEG_SCF_FBW7_1	0.1389
p.L389P	SIDM00499	Prostate Carcinoma	GDSC	MSTPEAT	DEG_SCF_FBW7_1	0.25
p.L389P	SIDM00475	Ovarian Carcinoma	GDSC	MSTPEAT	DEG_SCF_FBW7_1	0.25
p.L389P	SIDM00657	Acute Myeloid Leukemia	GDSC	MSTPEAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40967	Melanocyte protein PMEL	DEG_SCF_FBW7_1	392:398	MSTPEAT	FBXW7	0.9697	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons