DegronMD

Uniprot ID: Q9ULD2

Source protein: Microtubule-associated tumor suppressor 1

Source gene: MTUS1

Class: DEG_SCF_FBW7_2

Location: 428:434

E3 ligase: FBXW7

DEGRON score: 0.9685

ASA_SCORE: 94.6286

COIL: 0.905

CONS_SCORE: 0.4283

DSS_SCORE: 0.332

HELIX: 0.0179

FCONS_SCORE: 1.2046

RIG_SCORE: 0.8026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K437Q	TCGA-AG-A002	READ	TCGA	MSTPVLE	DEG_SCF_FBW7_2	0.3611
p.M426T	TCGA-BR-8591	STAD	TCGA	MSTPVLE	DEG_SCF_FBW7_2	0.2778
p.M426T	DO47973	STAD	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.2778
p.V438I	TCGA-D1-A17Q	UCEC	TCGA	MSTPVLE	DEG_SCF_FBW7_2	0.2222
p.V438I	DO41903	UCEC	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.2222
p.P444L	TCGA-EB-A3Y6	SKCM	TCGA	MSTPVLE	DEG_SCF_FBW7_2	0.0556
p.P444L	DO38081	SKCM	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.0556
p.E434Q	DO1112	BRCA	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.6744
p.P435R	DO222482	ESCA	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.3056
p.S429L	DO220902	MELA	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.6556
p.M428T	DO33091	PACA	ICGC	MSTPVLE	DEG_SCF_FBW7_2	0.7423
p.M418R	SIDM00690	Head and Neck Carcinoma	GDSC	MSTPVLE	DEG_SCF_FBW7_2	0.0556
p.M418R	SIDM00879	Breast Carcinoma	GDSC	MSTPVLE	DEG_SCF_FBW7_2	0.0556
p.L433P	SIDM00694	Other Solid Cancers	GDSC	MSTPVLE	DEG_SCF_FBW7_2	0.6471
p.L421S	TGW	autonomic_ganglia	COSMIC	MSTPVLE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SCF_FBW7_2	428:434	MSTPVLE	FBXW7	0.9685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons