DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
MSWTPAET
Uniprot ID:
Q6P1R3
Source protein:
Myb/SANT-like DNA-binding domain-containing protein 2
Source gene:
MSANTD2
Class:
DEG_SCF_FBW7_1
Location:
102:109
E3 ligase:
FBXW7
DEGRON score:
0.8311
ASA_SCORE:
51.2375
COIL:
0.4811
CONS_SCORE:
0.6597
DSS_SCORE:
0.1955
HELIX:
0.4981
FCONS_SCORE:
1.2799
RIG_SCORE:
0.8058
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E108G
DO227906
COCA
ICGC
MSWTPAET
DEG_SCF_FBW7_1
0.6087
p.A107S
DO27889
ORCA
ICGC
MSWTPAET
DEG_SCF_FBW7_1
0.6477
Drug responses associated with MSANTD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MSWTPAET
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6P1R3
Myb/SANT-like DNA-binding domain-containing protein 2
DEG_SCF_FBW7_1
102:109
MSWTPAET
FBXW7
0.8311
More...