DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MTLFSD
Uniprot ID:
Q1W209
Source protein:
Embryonic stem cell-related gene protein
Source gene:
ESRG
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8887
ASA_SCORE:
96.0667
COIL:
0.8488
CONS_SCORE:
0
DSS_SCORE:
0.6744
HELIX:
0.0578
FCONS_SCORE:
0
RIG_SCORE:
0.7907
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ESRG mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTLFSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q1W209
Embryonic stem cell-related gene protein
LIG_APCC_ABBA_1
1:6
MTLFSD
APC,CDC20,FZR1
0.8887
More...