DegronMD

Uniprot ID: Q2VY69

Source protein: Zinc finger protein 284

Source gene: ZNF284

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6605

ASA_SCORE: 112.9833

COIL: 0.952

CONS_SCORE: 0.2922

DSS_SCORE: 0.4744

HELIX: 0.0147

FCONS_SCORE: 1.6809

RIG_SCORE: 0.845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V13M	TCGA-05-4424	LUAD	TCGA	MTMFKE	LIG_APCC_ABBA_1	0.1389
p.V13M	DO23672	LUAD	ICGC	MTMFKE	LIG_APCC_ABBA_1	0.1389
p.A14V	TCGA-AP-A059	UCEC	TCGA	MTMFKE	LIG_APCC_ABBA_1	0.1111
p.A14V	DO41361	UCEC	ICGC	MTMFKE	LIG_APCC_ABBA_1	0.1111
p.T9I	TCGA-CG-5717	STAD	TCGA	MTMFKE	LIG_APCC_ABBA_1	0.25
p.T9I	DO38272	STAD	ICGC	MTMFKE	LIG_APCC_ABBA_1	0.25
p.K11R	DO234281	ESAD	ICGC	MTMFKE	LIG_APCC_ABBA_1	0.3056
p.K5N	DO229022	LICA	ICGC	MTMFKE	LIG_APCC_ABBA_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VY69	Zinc finger protein 284	LIG_APCC_ABBA_1	1:6	MTMFKE	APC,CDC20,FZR1	0.6605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons