DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MTPAET
Uniprot ID:
P84996
Source protein:
Protein ALEX
Source gene:
GNAS
Class:
DEG_SCF_FBW7_1
Location:
512:517
E3 ligase:
FBXW7
DEGRON score:
0.996
ASA_SCORE:
100.9
COIL:
0.9605
CONS_SCORE:
0.5034
DSS_SCORE:
0.6122
HELIX:
0.0147
FCONS_SCORE:
0.931
RIG_SCORE:
0.7025
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTPAET
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P84996
Protein ALEX
DEG_SCF_FBW7_1
512:517
MTPAET
FBXW7
0.996
More...