DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
MTPFGT
Uniprot ID:
Q03468
Source protein:
DNA excision repair protein ERCC-6
Source gene:
ERCC6
Class:
DEG_SCF_FBW7_1
Location:
245:250
E3 ligase:
FBXW7
DEGRON score:
0.9993
ASA_SCORE:
70.2167
COIL:
0.8618
CONS_SCORE:
0.315
DSS_SCORE:
0.589
HELIX:
0.055
FCONS_SCORE:
1.1348
RIG_SCORE:
0.732
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERCC6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTPFGT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q03468
DNA excision repair protein ERCC-6
DEG_SCF_FBW7_1
245:250
MTPFGT
FBXW7
0.9993
More...