DegronMD

Uniprot ID: Q6X4T0

Source protein: Uncharacterized protein C12orf54

Source gene: C12orf54

Class: DEG_SCF_FBW7_1

Location: 71:76

E3 ligase: FBXW7

DEGRON score: 0.6204

ASA_SCORE: 68.6667

COIL: 0.5952

CONS_SCORE: 0.5001

DSS_SCORE: 0.6513

HELIX: 0.059

FCONS_SCORE: 1.0233

RIG_SCORE: 0.6497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T72A	TCGA-AA-3984	COAD	TCGA	MTPMTS	DEG_SCF_FBW7_1	0.7139
p.T72A	DO9002	COAD	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.7139
p.P85H	TCGA-AX-A1CE	UCEC	TCGA	MTPMTS	DEG_SCF_FBW7_1	0.0833
p.P85H	DO42280	UCEC	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0833
p.I83T	TCGA-D1-A174	UCEC	TCGA	MTPMTS	DEG_SCF_FBW7_1	0.1389
p.I83T	DO40900	UCEC	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.1389
p.R79K	TCGA-EB-A41A	SKCM	TCGA	MTPMTS	DEG_SCF_FBW7_1	0.25
p.R79K	DO37429	SKCM	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.25
p.P86S	DO228483	BRCA	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO229016	COCA	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO229005	COCA	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO230659	LAML	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO231140	LAML	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO230929	LUSC	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO230993	LUSC	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.P86S	DO52365	LUSC	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.0556
p.M71I	DO228952	LICA	ICGC	MTPMTS	DEG_SCF_FBW7_1	0.6507
p.R62Q	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	MTPMTS	DEG_SCF_FBW7_1	0.0833
p.A77T	SIDM00014	Colorectal Carcinoma	GDSC	MTPMTS	DEG_SCF_FBW7_1	0.3056
p.M66L	SIDM00542	Glioblastoma	GDSC	MTPMTS	DEG_SCF_FBW7_1	0.1944
p.R79M	ACH-001369	Ovarian Cancer	CCLE	MTPMTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6X4T0	Uncharacterized protein C12orf54	DEG_SCF_FBW7_1	71:76	MTPMTS	FBXW7	0.6204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons