DegronMD

Uniprot ID: Q8TDU6

Source protein: G-protein coupled bile acid receptor 1

Source gene: GPBAR1

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.938

ASA_SCORE: 85.7167

COIL: 0.9457

CONS_SCORE: 0.5106

DSS_SCORE: 0.8904

HELIX: 0.0248

FCONS_SCORE: 1.0627

RIG_SCORE: 0.6329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3S	TCGA-AG-A02N	READ	TCGA	MTPNST	DEG_SCF_FBW7_1	0.6752
p.P3S	DO37146	READ	ICGC	MTPNST	DEG_SCF_FBW7_1	0.6752
p.T2M	TCGA-E1-A7YS	LGG	TCGA	MTPNST	DEG_SCF_FBW7_1	0.7423
p.T2M	TCGA-NH-A5IV	COAD	TCGA	MTPNST	DEG_SCF_FBW7_1	0.7423
p.T2M	DO49095	COAD	ICGC	MTPNST	DEG_SCF_FBW7_1	0.7423
p.T2M	DO219799	LGG	ICGC	MTPNST	DEG_SCF_FBW7_1	0.7423
p.G16E	DO222875	MELA	ICGC	MTPNST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDU6	G-protein coupled bile acid receptor 1	DEG_SCF_FBW7_1	1:6	MTPNST	FBXW7	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons