DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MTRTPVGS
Uniprot ID:
Q6ZUU3
Source protein:
FOXL2 neighbor protein
Source gene:
FOXL2NB
Class:
DEG_SCF_FBW7_1
Location:
1:8
E3 ligase:
FBXW7
DEGRON score:
0.7926
ASA_SCORE:
102.9125
COIL:
0.9323
CONS_SCORE:
1
DSS_SCORE:
0.9629
HELIX:
0.035
FCONS_SCORE:
1
RIG_SCORE:
0.6675
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FOXL2NB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MTRTPVGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZUU3
FOXL2 neighbor protein
DEG_SCF_FBW7_1
1:8
MTRTPVGS
FBXW7
0.7926
More...