DegronMD

Uniprot ID: Q02241

Source protein: Kinesin-like protein KIF23

Source gene: KIF23

Class: LIG_APCC_ABBA_1

Location: 385:390

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5979

ASA_SCORE: 75.9833

COIL: 0.7878

CONS_SCORE: 0.5546

DSS_SCORE: 0.2699

HELIX: 0.0893

FCONS_SCORE: 0.9807

RIG_SCORE: 0.834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F397L	TCGA-F7-A61V	HNSC	TCGA	MVPYRD	LIG_APCC_ABBA_1	0.1389
p.Y399S	DO224539	LUSC	ICGC	MVPYRD	LIG_APCC_ABBA_1	0.0833
p.Y399S	DO231010	LUSC	ICGC	MVPYRD	LIG_APCC_ABBA_1	0.0833
p.T395I	DO47096	RECA	ICGC	MVPYRD	LIG_APCC_ABBA_1	0.1944
p.T396N	DO41361	UCEC	ICGC	MVPYRD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02241	Kinesin-like protein KIF23	LIG_APCC_ABBA_1	385:390	MVPYRD	APC,CDC20,FZR1	0.5979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons