DegronMD

Uniprot ID: Q9UDY8

Source protein: Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Source gene: MALT1

Class: LIG_APCC_ABBA_1

Location: 276:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6121

ASA_SCORE: 54.6167

COIL: 0.5913

CONS_SCORE: 0.28

DSS_SCORE: 0.1388

HELIX: 0.0372

FCONS_SCORE: 0.8223

RIG_SCORE: 0.8828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M276I	TCGA-09-2044	OV	TCGA	MVPYVD	LIG_APCC_ABBA_1	0.6507
p.M276I	DO28923	OV	ICGC	MVPYVD	LIG_APCC_ABBA_1	0.6507
p.W289L	DO229034	LICA	ICGC	MVPYVD	LIG_APCC_ABBA_1	0.1111
p.Y275C	SIDM01254	Burkitt's Lymphoma	GDSC	MVPYVD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDY8	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	LIG_APCC_ABBA_1	276:281	MVPYVD	APC,CDC20,FZR1	0.6121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons