DegronMD

Uniprot ID: Q9NPY3

Source protein: Complement component C1q receptor

Source gene: CD93

Class: CBL_PTK

Location: 623:632

E3 ligase: CBL

DEGRON score: 0.7458

ASA_SCORE: 32.22

COIL: 0.5622

CONS_SCORE: 0.5079

DSS_SCORE: 0.5687

HELIX: 0.1716

FCONS_SCORE: 1.1149

RIG_SCORE: 0.7004

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E636G	TCGA-86-8074	LUAD	TCGA	NAADSYSWVP	CBL_PTK	0.2222
p.E636G	DO25330	LUAD	ICGC	NAADSYSWVP	CBL_PTK	0.2222
p.A625T	TCGA-A6-2686	COAD	TCGA	NAADSYSWVP	CBL_PTK	0.6028
p.A625T	TCGA-HU-A4GT	STAD	TCGA	NAADSYSWVP	CBL_PTK	0.6028
p.A625T	DO7828	COAD	ICGC	NAADSYSWVP	CBL_PTK	0.6028
p.A625T	DO48020	STAD	ICGC	NAADSYSWVP	CBL_PTK	0.6028
p.A624V	TCGA-AA-3977	COAD	TCGA	NAADSYSWVP	CBL_PTK	0.5825
p.A624V	DO8730	COAD	ICGC	NAADSYSWVP	CBL_PTK	0.5825
p.A624V	DO33432	PACA	ICGC	NAADSYSWVP	CBL_PTK	0.5825
p.A624V	SIDM01943	Colorectal Carcinoma	GDSC	NAADSYSWVP	CBL_PTK	0.5825
p.E618K	TCGA-BR-8678	STAD	TCGA	NAADSYSWVP	CBL_PTK	0.1944
p.E618K	TCGA-EE-A2GC	SKCM	TCGA	NAADSYSWVP	CBL_PTK	0.1944
p.E618K	DO220912	MELA	ICGC	NAADSYSWVP	CBL_PTK	0.1944
p.E618K	DO37839	SKCM	ICGC	NAADSYSWVP	CBL_PTK	0.1944
p.E618K	DO47957	STAD	ICGC	NAADSYSWVP	CBL_PTK	0.1944
p.S629F	TCGA-EB-A24D	SKCM	TCGA	NAADSYSWVP	CBL_PTK	0.9093
p.S629F	TCGA-L5-A8NM	ESCA	TCGA	NAADSYSWVP	CBL_PTK	0.9093
p.S629F	DO222837	MELA	ICGC	NAADSYSWVP	CBL_PTK	0.9093
p.S629F	DO37440	SKCM	ICGC	NAADSYSWVP	CBL_PTK	0.9093
p.P632L	TCGA-EE-A2MF	SKCM	TCGA	NAADSYSWVP	CBL_PTK	0.7582
p.P632L	DO222491	MELA	ICGC	NAADSYSWVP	CBL_PTK	0.7582
p.P632L	DO51249	SKCM	ICGC	NAADSYSWVP	CBL_PTK	0.7582
p.E618Q	TCGA-MV-A51V	BLCA	TCGA	NAADSYSWVP	CBL_PTK	0.1944
p.E618Q	DO474	BLCA	ICGC	NAADSYSWVP	CBL_PTK	0.1944
p.M640V	DO229013	COCA	ICGC	NAADSYSWVP	CBL_PTK	0.1111
p.M640V	DO229016	COCA	ICGC	NAADSYSWVP	CBL_PTK	0.1111
p.M640V	DO229003	COCA	ICGC	NAADSYSWVP	CBL_PTK	0.1111
p.M640V	DO229005	COCA	ICGC	NAADSYSWVP	CBL_PTK	0.1111
p.M640V	DO230554	LUSC	ICGC	NAADSYSWVP	CBL_PTK	0.1111
p.N642K	DO228971	LICA	ICGC	NAADSYSWVP	CBL_PTK	0.0556
p.P632Q	DO231778	LINC	ICGC	NAADSYSWVP	CBL_PTK	0.7035
p.S637C	SIDM01134	Small Cell Lung Carcinoma	GDSC	NAADSYSWVP	CBL_PTK	0.6389
p.S637C	ACH-000292	Lung Cancer	CCLE	NAADSYSWVP	CBL_PTK	0.6389
p.S637C	NCI-H841	lung	COSMIC	NAADSYSWVP	CBL_PTK	0.6389
p.S627N	SIDM00224	Mesothelioma	GDSC	NAADSYSWVP	CBL_PTK	0.7069
p.S627N	IST-MES1	pleura	COSMIC	NAADSYSWVP	CBL_PTK	0.7069
p.R634Q	SIDM01768	Melanoma	GDSC	NAADSYSWVP	CBL_PTK	0.2778
p.R634Q	ACH-000899	Skin Cancer	CCLE	NAADSYSWVP	CBL_PTK	0.2778
p.P632S	ACH-001567	Skin Cancer	CCLE	NAADSYSWVP	CBL_PTK	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NAADSYSWVP

Degron related mutations and impact score

Drug responses associated with CD93 mutations

All proteins holding degron of NAADSYSWVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPY3	Complement component C1q receptor	CBL_PTK	623:632	NAADSYSWVP	CBL	0.7458	More...