DegronMD

Uniprot ID: Q9Y5F0

Source protein: Protocadherin beta-13

Source gene: PCDHB13

Class: CBL_PTK

Location: 483:492

E3 ligase: CBL

DEGRON score: 0.7162

ASA_SCORE: 25.07

COIL: 0.2434

CONS_SCORE: 0.6595

DSS_SCORE: 0.528

HELIX: 0.0133

FCONS_SCORE: 1.2938

RIG_SCORE: 0.7426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S474N	TCGA-12-1598	GBM	TCGA	NAQVTYSLLP	CBL_PTK	0.0833
p.S474N	DO10871	GBM	ICGC	NAQVTYSLLP	CBL_PTK	0.0833
p.P492A	TCGA-13-1477	OV	TCGA	NAQVTYSLLP	CBL_PTK	0.7503
p.P492A	DO27978	OV	ICGC	NAQVTYSLLP	CBL_PTK	0.7503
p.A475T	TCGA-2W-A8YY	CESC	TCGA	NAQVTYSLLP	CBL_PTK	0.1111
p.A475T	DO223732	CESC	ICGC	NAQVTYSLLP	CBL_PTK	0.1111
p.S502F	TCGA-EB-A5UN	SKCM	TCGA	NAQVTYSLLP	CBL_PTK	0.0556
p.S502F	DO47267	SKCM	ICGC	NAQVTYSLLP	CBL_PTK	0.0556
p.D495N	TCGA-WE-A8K5	SKCM	TCGA	NAQVTYSLLP	CBL_PTK	0.25
p.D495N	DO51282	SKCM	ICGC	NAQVTYSLLP	CBL_PTK	0.25
p.D495N	SIDM00428	Acute Myeloid Leukemia	GDSC	NAQVTYSLLP	CBL_PTK	0.25
p.D495N	ACH-000294	Leukemia	CCLE	NAQVTYSLLP	CBL_PTK	0.25
p.D495N	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	NAQVTYSLLP	CBL_PTK	0.25
p.L491R	DO234406	ESAD	ICGC	NAQVTYSLLP	CBL_PTK	0.7316
p.T487I	DO231075	LUSC	ICGC	NAQVTYSLLP	CBL_PTK	0.5966
p.A484T	DO49118	PACA	ICGC	NAQVTYSLLP	CBL_PTK	0.6028
p.T476I	DO229221	THCA	ICGC	NAQVTYSLLP	CBL_PTK	0.1389
p.P493S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	NAQVTYSLLP	CBL_PTK	0.3056
p.P493S	ACH-000843	Lung Cancer	CCLE	NAQVTYSLLP	CBL_PTK	0.3056
p.P493S	HARA	lung	COSMIC	NAQVTYSLLP	CBL_PTK	0.3056
p.A475P	SIDM00719	Small Cell Lung Carcinoma	GDSC	NAQVTYSLLP	CBL_PTK	0.1111
p.A475P	ACH-001364	Lung Cancer	CCLE	NAQVTYSLLP	CBL_PTK	0.1111
p.A475P	NCI-H345	lung	COSMIC	NAQVTYSLLP	CBL_PTK	0.1111
p.T476K	SIDM00364	B-Lymphoblastic Leukemia	GDSC	NAQVTYSLLP	CBL_PTK	0.1389
p.T476K	ACH-002059	Leukemia	CCLE	NAQVTYSLLP	CBL_PTK	0.1389
p.T476K	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	NAQVTYSLLP	CBL_PTK	0.1389
p.T501I	SIDM00251	Gastric Carcinoma	GDSC	NAQVTYSLLP	CBL_PTK	0.0833
p.T501I	ACH-000949	Gastric Cancer	CCLE	NAQVTYSLLP	CBL_PTK	0.0833
p.T501I	TGBC11TKB	stomach	COSMIC	NAQVTYSLLP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5F0	Protocadherin beta-13	CBL_PTK	483:492	NAQVTYSLLP	CBL	0.7162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NAQVTYSLLP

Degron related mutations and impact score

Drug responses associated with PCDHB13 mutations

All proteins holding degron of NAQVTYSLLP