DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NEKTYSESP
Uniprot ID:
Q7Z3E2
Source protein:
Coiled-coil domain-containing protein 186
Source gene:
CCDC186
Class:
CBL_PTK
Location:
132:140
E3 ligase:
CBL
DEGRON score:
0.5884
ASA_SCORE:
107.3
COIL:
0.6849
CONS_SCORE:
0.2717
DSS_SCORE:
0.5061
HELIX:
0.2924
FCONS_SCORE:
0.9355
RIG_SCORE:
0.7016
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S124L
SIDM00216
Colorectal Carcinoma
GDSC
NEKTYSESP
CBL_PTK
0.1111
p.S124L
SNU-175
large_intestine
COSMIC
NEKTYSESP
CBL_PTK
0.1111
Drug responses associated with CCDC186 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NEKTYSESP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z3E2
Coiled-coil domain-containing protein 186
CBL_PTK
132:140
NEKTYSESP
CBL
0.5884
More...
