DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NGYSPVP
Uniprot ID:
Q5SZQ8
Source protein:
CUGBP Elav-like family member 3
Source gene:
CELF3
Class:
CBL_PTK
Location:
280:286
E3 ligase:
CBL
DEGRON score:
0.9117
ASA_SCORE:
46.0429
COIL:
0.897
CONS_SCORE:
0.3052
DSS_SCORE:
0.5167
HELIX:
0.0201
FCONS_SCORE:
0.8916
RIG_SCORE:
0.6509
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G281S
TCGA-EO-A22U
UCEC
TCGA
NGYSPVP
CBL_PTK
0.5882
p.G281S
TCGA-G3-A25S
LIHC
TCGA
NGYSPVP
CBL_PTK
0.5882
p.G281S
TCGA-QQ-A8VF
SARC
TCGA
NGYSPVP
CBL_PTK
0.5882
p.G281S
DO23018
LIHC
ICGC
NGYSPVP
CBL_PTK
0.5882
p.G281S
DO220258
SARC
ICGC
NGYSPVP
CBL_PTK
0.5882
p.G281S
DO43755
UCEC
ICGC
NGYSPVP
CBL_PTK
0.5882
p.L277M
TCGA-EY-A215
UCEC
TCGA
NGYSPVP
CBL_PTK
0.25
p.L277M
DO42665
UCEC
ICGC
NGYSPVP
CBL_PTK
0.25
p.P295H
TCGA-VS-A9UB
CESC
TCGA
NGYSPVP
CBL_PTK
0.0833
p.P295H
DO219731
CESC
ICGC
NGYSPVP
CBL_PTK
0.0833
p.P286S
DO50970
LICA
ICGC
NGYSPVP
CBL_PTK
0.6752
p.P295S
SIDM01409
Bladder Carcinoma
GDSC
NGYSPVP
CBL_PTK
0.0833
Drug responses associated with CELF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGYSPVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SZQ8
CUGBP Elav-like family member 3
CBL_PTK
280:286
NGYSPVP
CBL
0.9117
More...
