DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NHNANYSSMP
Uniprot ID:
Q17R89
Source protein:
Rho GTPase-activating protein 44
Source gene:
ARHGAP44
Class:
CBL_PTK
Location:
464:473
E3 ligase:
CBL
DEGRON score:
0.7663
ASA_SCORE:
87.27
COIL:
0.8665
CONS_SCORE:
0.3498
DSS_SCORE:
0.5559
HELIX:
0.1032
FCONS_SCORE:
1.057
RIG_SCORE:
0.6226
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R482L
TCGA-17-Z016
LUAD
TCGA
NHNANYSSMP
CBL_PTK
0.0833
p.R483L
TCGA-44-3918
LUAD
TCGA
NHNANYSSMP
CBL_PTK
0.0556
p.R483L
DO23732
LUAD
ICGC
NHNANYSSMP
CBL_PTK
0.0556
p.A467V
TCGA-77-8156
LUSC
TCGA
NHNANYSSMP
CBL_PTK
0.5825
p.A467V
DO26802
LUSC
ICGC
NHNANYSSMP
CBL_PTK
0.5825
p.D476N
TCGA-B5-A1MR
UCEC
TCGA
NHNANYSSMP
CBL_PTK
0.25
p.D476N
DO41758
UCEC
ICGC
NHNANYSSMP
CBL_PTK
0.25
p.P460L
TCGA-D3-A3MV
SKCM
TCGA
NHNANYSSMP
CBL_PTK
0.2222
p.P460L
DO37727
SKCM
ICGC
NHNANYSSMP
CBL_PTK
0.2222
p.P475Q
TCGA-EE-A3AG
SKCM
TCGA
NHNANYSSMP
CBL_PTK
0.2778
p.P475Q
TCGA-ER-A19O
SKCM
TCGA
NHNANYSSMP
CBL_PTK
0.2778
p.P475Q
DO37471
SKCM
ICGC
NHNANYSSMP
CBL_PTK
0.2778
p.P475Q
DO38063
SKCM
ICGC
NHNANYSSMP
CBL_PTK
0.2778
p.S471L
DO229054
LICA
ICGC
NHNANYSSMP
CBL_PTK
0.6556
p.D478N
DO220897
MELA
ICGC
NHNANYSSMP
CBL_PTK
0.1944
p.D478N
DO222731
MELA
ICGC
NHNANYSSMP
CBL_PTK
0.1944
p.D478N
ACH-001521
Skin Cancer
CCLE
NHNANYSSMP
CBL_PTK
0.1944
p.P479R
ACH-001548
Neuroblastoma
CCLE
NHNANYSSMP
CBL_PTK
0.1667
Drug responses associated with ARHGAP44 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NHNANYSSMP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q17R89
Rho GTPase-activating protein 44
CBL_PTK
464:473
NHNANYSSMP
CBL
0.7663
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