DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: CBL_PTK

Location: 1059:1068

E3 ligase: CBL

DEGRON score: 0.7721

ASA_SCORE: 78.61

COIL: 0.6393

CONS_SCORE: 0.4969

DSS_SCORE: 0.4886

HELIX: 0.0169

FCONS_SCORE: 1.0257

RIG_SCORE: 0.7724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1049P	TCGA-66-2759	LUSC	TCGA	NHQVVYTTLP	CBL_PTK	0.0556
p.P1071L	TCGA-73-4659	LUAD	TCGA	NHQVVYTTLP	CBL_PTK	0.25
p.V1053L	TCGA-90-7769	LUSC	TCGA	NHQVVYTTLP	CBL_PTK	0.1667
p.P1070L	DO24467	LUAD	ICGC	NHQVVYTTLP	CBL_PTK	0.2778
p.V1052L	DO26822	LUSC	ICGC	NHQVVYTTLP	CBL_PTK	0.1389
p.R1076Q	DO51494	PACA	ICGC	NHQVVYTTLP	CBL_PTK	0.1111
p.R1076Q	LU-135	lung	COSMIC	NHQVVYTTLP	CBL_PTK	0.1111
p.T1065N	DO229227	THCA	ICGC	NHQVVYTTLP	CBL_PTK	0.7055
p.P1065A	SIDM00569	Osteosarcoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SIDM00581	Glioblastoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SIDM00214	Colorectal Carcinoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SIDM00242	Osteosarcoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SIDM01147	Gastric Carcinoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SIDM00045	Gastric Carcinoma	GDSC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	GB-1	central_nervous_system	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	HSC-39	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	NY	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	NOS-1	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	SNU-407	large_intestine	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.P1065A	NCI-N87	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.7503
p.T1073R	SIDM01160	Bladder Carcinoma	GDSC	NHQVVYTTLP	CBL_PTK	0.1944
p.T1073R	SW780	urinary_tract	COSMIC	NHQVVYTTLP	CBL_PTK	0.1944
p.T1065R	ACH-000384	Bladder Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.7876
p.T1065R	SW780	urinary_tract	COSMIC	NHQVVYTTLP	CBL_PTK	0.7876
p.P1057A	ACH-000427	Gastric Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-000738	Brain Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-000791	Lung Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-000955	Colon/Colorectal Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-001100		CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-001197	Lymphoma	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-001786	Colon/Colorectal Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-002067	Bone Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-002141	Gastric Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	ACH-002178	Bone Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	HSC-39	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	NOS-1	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	SNU-407	large_intestine	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	NY	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	NCI-N87	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.P1057A	GB-1	central_nervous_system	COSMIC	NHQVVYTTLP	CBL_PTK	0.2778
p.R1077Q	ACH-001549	Lung Cancer	CCLE	NHQVVYTTLP	CBL_PTK	0.0833
p.R1077Q	LU-135	lung	COSMIC	NHQVVYTTLP	CBL_PTK	0.0833
p.P1056A	NY	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.P1056A	NOS-1	bone	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.P1056A	HSC-39	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.P1056A	NCI-N87	stomach	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.P1056A	SNU-407	large_intestine	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.P1056A	GB-1	central_nervous_system	COSMIC	NHQVVYTTLP	CBL_PTK	0.25
p.T1064R	SW780	urinary_tract	COSMIC	NHQVVYTTLP	CBL_PTK	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NHQVVYTTLP

Degron related mutations and impact score

Drug responses associated with ATF7IP mutations

All proteins holding degron of NHQVVYTTLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	CBL_PTK	1059:1068	NHQVVYTTLP	CBL	0.7721	More...