DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NISSADYTQDP
Uniprot ID:
Q96EG1
Source protein:
Arylsulfatase G
Source gene:
ARSG
Class:
CBL_PTK
Location:
497:507
E3 ligase:
CBL
DEGRON score:
0.9072
ASA_SCORE:
78.7
COIL:
0.8143
CONS_SCORE:
0.379
DSS_SCORE:
0.3347
HELIX:
0.1585
FCONS_SCORE:
1.0402
RIG_SCORE:
0.7493
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V489I
TCGA-2W-A8YY
CESC
TCGA
NISSADYTQDP
CBL_PTK
0.1111
p.V489I
TCGA-AX-A1CE
UCEC
TCGA
NISSADYTQDP
CBL_PTK
0.1111
p.V489I
DO223732
CESC
ICGC
NISSADYTQDP
CBL_PTK
0.1111
p.V489I
DO42280
UCEC
ICGC
NISSADYTQDP
CBL_PTK
0.1111
p.A501T
TCGA-D1-A103
UCEC
TCGA
NISSADYTQDP
CBL_PTK
0.6028
p.A501T
DO42312
UCEC
ICGC
NISSADYTQDP
CBL_PTK
0.6028
p.S500R
TCGA-DI-A1BU
UCEC
TCGA
NISSADYTQDP
CBL_PTK
0.6316
p.S500R
DO42023
UCEC
ICGC
NISSADYTQDP
CBL_PTK
0.6316
p.Y503H
TCGA-EE-A3J7
SKCM
TCGA
NISSADYTQDP
CBL_PTK
0.7229
p.Y503H
DO48770
SKCM
ICGC
NISSADYTQDP
CBL_PTK
0.7229
p.Y503H
SIDM01293
Colorectal Carcinoma
GDSC
NISSADYTQDP
CBL_PTK
0.7229
p.I493T
DO228751
EOPC
ICGC
NISSADYTQDP
CBL_PTK
0.2222
p.A494T
DO33084
PACA
ICGC
NISSADYTQDP
CBL_PTK
0.25
p.Q517K
ACH-000889
Myeloma
CCLE
NISSADYTQDP
CBL_PTK
0.0556
p.T510N
ACH-001403
Ovarian Cancer
CCLE
NISSADYTQDP
CBL_PTK
0.25
Drug responses associated with ARSG mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NISSADYTQDP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96EG1
Arylsulfatase G
CBL_PTK
497:507
NISSADYTQDP
CBL
0.9072
More...
