DegronMD

Uniprot ID: Q15223

Source protein: Nectin-1

Source gene: NECTIN1

Class: CBL_PTK

Location: 332:342

E3 ligase: CBL

DEGRON score: 0.7045

ASA_SCORE: 65.1727

COIL: 0.621

CONS_SCORE: 0.4348

DSS_SCORE: 0.5578

HELIX: 0.0055

FCONS_SCORE: 0.9202

RIG_SCORE: 0.7351

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R350M	SIDM00773	Non-Cancerous	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01090	Colorectal Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01117	Small Cell Lung Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM00690	Head and Neck Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM00774	Breast Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01318	Hepatocellular Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.R350M	SIDM01752	Pancreatic Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.1111
p.E330K	SIDM00210	Ovarian Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.2778
p.E330K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	NITEFPYTPSP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15223	Nectin-1	CBL_PTK	332:342	NITEFPYTPSP	CBL	0.7045	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons