DegronMD

Uniprot ID: P12318

Source protein: Low affinity immunoglobulin gamma Fc region receptor II-a

Source gene: FCGR2A

Class: DEG_Kelch_Keap1_1

Location: 96:101

E3 ligase: KEAP1

DEGRON score: 0.5645

ASA_SCORE: 71.6833

COIL: 0.7142

CONS_SCORE: 0.7411

DSS_SCORE: 0.4852

HELIX: 0.0317

FCONS_SCORE: 1.0536

RIG_SCORE: 0.6603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C104Y	TCGA-3B-A9HO	SARC	TCGA	NNDSGE	DEG_Kelch_Keap1_1	0.25
p.C104Y	DO219929	SARC	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.25
p.T103M	TCGA-VQ-A91E	STAD	TCGA	NNDSGE	DEG_Kelch_Keap1_1	0.2778
p.T103M	DO51784	STAD	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.2778
p.P88A	DO224999	BRCA	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.1111
p.T86M	DO10840	ESAD	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.0556
p.G100R	DO234189	ESAD	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.7568
p.A94S	DO228976	LICA	ICGC	NNDSGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12318	Low affinity immunoglobulin gamma Fc region receptor II-a	DEG_Kelch_Keap1_1	96:101	NNDSGE	KEAP1	0.5645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons