DegronMD

Uniprot ID: Q9NQS1

Source protein: Cell death regulator Aven

Source gene: AVEN

Class: DEG_Kelch_Keap1_1

Location: 129:134

E3 ligase: KEAP1

DEGRON score: 0.5346

ASA_SCORE: 97.1833

COIL: 0.8148

CONS_SCORE: 0.4012

DSS_SCORE: 0.5628

HELIX: 0.1558

FCONS_SCORE: 0.6148

RIG_SCORE: 0.6718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V128F	TCGA-64-5815	LUAD	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.3056
p.V128F	DO23578	LUAD	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.3056
p.L144I	TCGA-78-7159	LUAD	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.0556
p.L144I	DO23568	LUAD	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.0556
p.E131Q	TCGA-90-A4EE	LUSC	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.6744
p.E131Q	DO45513	LUSC	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.6744
p.R120Q	TCGA-AG-A002	READ	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.0833
p.R120Q	TCGA-EY-A1GD	UCEC	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.0833
p.R120Q	DO42129	UCEC	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.0833
p.D140Y	TCGA-AP-A056	UCEC	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.1667
p.D140Y	TCGA-VQ-A8P2	STAD	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.1667
p.D140Y	DO51761	STAD	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.1667
p.D140Y	DO43971	UCEC	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.1667
p.S135L	TCGA-FR-A726	SKCM	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.75
p.S135L	DO48665	SKCM	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.75
p.N129S	TCGA-VP-AA1N	PRAD	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.5958
p.N129S	DO51393	PRAD	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.5958
p.G133R	TCGA-VQ-A924	STAD	TCGA	NNESGE	DEG_Kelch_Keap1_1	0.7568
p.G133R	DO51795	STAD	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.7568
p.I124T	DO23332	LINC	ICGC	NNESGE	DEG_Kelch_Keap1_1	0.1944
p.I124V	ACH-002065	Sarcoma	CCLE	NNESGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQS1	Cell death regulator Aven	DEG_Kelch_Keap1_1	129:134	NNESGE	KEAP1	0.5346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons