DegronMD

Uniprot ID: Q7L945

Source protein: Zinc finger protein 627

Source gene: ZNF627

Class: DEG_SIAH_1

Location: 451:459

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9948

ASA_SCORE: 78.0556

COIL: 0.817

CONS_SCORE: 0.4771

DSS_SCORE: 0.695

HELIX: 0.0529

FCONS_SCORE: 0.6593

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P458Q	TCGA-D3-A2JC	SKCM	TCGA	NPNASVVPV	DEG_SIAH_1	0.7035
p.P458Q	DO47578	SKCM	ICGC	NPNASVVPV	DEG_SIAH_1	0.7035
p.K445N	TCGA-D9-A6EC	SKCM	TCGA	NPNASVVPV	DEG_SIAH_1	0.2778
p.K445N	DO50291	SKCM	ICGC	NPNASVVPV	DEG_SIAH_1	0.2778
p.P458S	TCGA-EE-A2A2	SKCM	TCGA	NPNASVVPV	DEG_SIAH_1	0.6752
p.P458S	DO37583	SKCM	ICGC	NPNASVVPV	DEG_SIAH_1	0.6752
p.L460I	DO7801	COAD	ICGC	NPNASVVPV	DEG_SIAH_1	0.3056
p.L460I	DO222762	COCA	ICGC	NPNASVVPV	DEG_SIAH_1	0.3056
p.L460I	DO222884	COCA	ICGC	NPNASVVPV	DEG_SIAH_1	0.3056
p.H441R	DO48761	LIRI	ICGC	NPNASVVPV	DEG_SIAH_1	0.0556
p.E448V	SIDM00789	Colorectal Carcinoma	GDSC	NPNASVVPV	DEG_SIAH_1	0.25
p.E448V	HCT-15	large_intestine	COSMIC	NPNASVVPV	DEG_SIAH_1	0.25
p.V457I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	NPNASVVPV	DEG_SIAH_1	0.5965
p.V457I	ACH-000824	Esophageal Cancer	CCLE	NPNASVVPV	DEG_SIAH_1	0.5965
p.V457I	KYSE-510	oesophagus	COSMIC	NPNASVVPV	DEG_SIAH_1	0.5965
p.T442A	SIDM00333	Endometrial Carcinoma	GDSC	NPNASVVPV	DEG_SIAH_1	0.5278
p.T442A	ACH-000988	Endometrial/Uterine Cancer	CCLE	NPNASVVPV	DEG_SIAH_1	0.5278
p.T442A	MFE-319	endometrium	COSMIC	NPNASVVPV	DEG_SIAH_1	0.5278
p.G443R	SIDM01608	Endometrial Carcinoma	GDSC	NPNASVVPV	DEG_SIAH_1	0.1111
p.G443R	ACH-000990	Endometrial/Uterine Cancer	CCLE	NPNASVVPV	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L945	Zinc finger protein 627	DEG_SIAH_1	451:459	NPNASVVPV	SIAH1,SIAH2,SIAH3	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons