DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPTKYTFFP
Uniprot ID:
Q8N2A8
Source protein:
Mitochondrial cardiolipin hydrolase
Source gene:
PLD6
Class:
CBL_PTK
Location:
210:218
E3 ligase:
CBL
DEGRON score:
0.9493
ASA_SCORE:
80.9
COIL:
0.8229
CONS_SCORE:
0.3404
DSS_SCORE:
0.2942
HELIX:
0.1441
FCONS_SCORE:
0.8161
RIG_SCORE:
0.807
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P211S
TCGA-29-1764
OV
TCGA
NPTKYTFFP
CBL_PTK
0.5641
p.P211S
DO28364
OV
ICGC
NPTKYTFFP
CBL_PTK
0.5641
p.P219S
TCGA-A2-A1FZ
BRCA
TCGA
NPTKYTFFP
CBL_PTK
0.3056
p.P219S
DO2770
BRCA
ICGC
NPTKYTFFP
CBL_PTK
0.3056
p.F216L
TCGA-AP-A05N
UCEC
TCGA
NPTKYTFFP
CBL_PTK
0.587
p.F216L
DO40851
UCEC
ICGC
NPTKYTFFP
CBL_PTK
0.587
p.R204H
TCGA-B7-A5TI
STAD
TCGA
NPTKYTFFP
CBL_PTK
0.1667
p.R204H
TCGA-FI-A2D5
UCEC
TCGA
NPTKYTFFP
CBL_PTK
0.1667
p.R204H
DO222328
STAD
ICGC
NPTKYTFFP
CBL_PTK
0.1667
p.R204H
DO41331
UCEC
ICGC
NPTKYTFFP
CBL_PTK
0.1667
p.P228Q
TCGA-CN-6010
HNSC
TCGA
NPTKYTFFP
CBL_PTK
0.0556
p.P228Q
DO14766
HNSC
ICGC
NPTKYTFFP
CBL_PTK
0.0556
p.P228Q
DO228948
LICA
ICGC
NPTKYTFFP
CBL_PTK
0.0556
p.K220N
TCGA-EI-6917
READ
TCGA
NPTKYTFFP
CBL_PTK
0.2778
p.K220N
DO36881
READ
ICGC
NPTKYTFFP
CBL_PTK
0.2778
p.F217S
TCGA-EO-A3AY
UCEC
TCGA
NPTKYTFFP
CBL_PTK
0.6871
p.F217S
DO43202
UCEC
ICGC
NPTKYTFFP
CBL_PTK
0.6871
p.E201Q
TCGA-FD-A6TC
BLCA
TCGA
NPTKYTFFP
CBL_PTK
0.0833
p.E201Q
TCGA-MA-AA41
CESC
TCGA
NPTKYTFFP
CBL_PTK
0.0833
p.E201Q
DO49755
BLCA
ICGC
NPTKYTFFP
CBL_PTK
0.0833
p.E201Q
DO219723
CESC
ICGC
NPTKYTFFP
CBL_PTK
0.0833
p.E203D
DO52598
BOCA
ICGC
NPTKYTFFP
CBL_PTK
0.1389
p.R204S
DO229028
LICA
ICGC
NPTKYTFFP
CBL_PTK
0.1667
p.P211T
DO229008
LICA
ICGC
NPTKYTFFP
CBL_PTK
0.5919
p.G224E
DO229459
SKCA
ICGC
NPTKYTFFP
CBL_PTK
0.1667
p.G224R
DO229459
SKCA
ICGC
NPTKYTFFP
CBL_PTK
0.1667
Drug responses associated with PLD6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPTKYTFFP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N2A8
Mitochondrial cardiolipin hydrolase
CBL_PTK
210:218
NPTKYTFFP
CBL
0.9493
More...