DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPVYSPVP
Uniprot ID:
Q9UPX6
Source protein:
Major intrinsically disordered Notch2-binding receptor 1
Source gene:
MINAR1
Class:
CBL_PTK
Location:
314:321
E3 ligase:
CBL
DEGRON score:
0.9856
ASA_SCORE:
89.175
COIL:
0.9548
CONS_SCORE:
0.7952
DSS_SCORE:
0.5236
HELIX:
0.0211
FCONS_SCORE:
0.8905
RIG_SCORE:
0.7224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M306L
SIDM00607
Glioblastoma
GDSC
NPVYSPVP
CBL_PTK
0.1111
p.M306L
SIDM00083
Glioblastoma
GDSC
NPVYSPVP
CBL_PTK
0.1111
Drug responses associated with MINAR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPVYSPVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPX6
Major intrinsically disordered Notch2-binding receptor 1
CBL_PTK
314:321
NPVYSPVP
CBL
0.9856
More...
