DegronMD

Uniprot ID: O14920

Source protein: Inhibitor of nuclear factor kappa-B kinase subunit beta

Source gene: IKBKB

Class: DEG_Kelch_Keap1_1

Location: 34:39

E3 ligase: KEAP1

DEGRON score: 0.9774

ASA_SCORE: 81.9667

COIL: 0.824

CONS_SCORE: 0.4589

DSS_SCORE: 0.3262

HELIX: 0.0067

FCONS_SCORE: 0.8625

RIG_SCORE: 0.7894

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N28I	TCGA-21-1080	LUSC	TCGA	NQETGE	DEG_Kelch_Keap1_1	0.1667
p.N28I	DO26502	LUSC	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.1667
p.N34K	TCGA-A5-A0G2	UCEC	TCGA	NQETGE	DEG_Kelch_Keap1_1	0.6918
p.N34S	TCGA-AX-A06F	UCEC	TCGA	NQETGE	DEG_Kelch_Keap1_1	0.5958
p.Q35E	TCGA-DK-A1AC	BLCA	TCGA	NQETGE	DEG_Kelch_Keap1_1	0.5633
p.I30M	TCGA-XF-A9SK	BLCA	TCGA	NQETGE	DEG_Kelch_Keap1_1	0.2222
p.M24I	DO52646	BOCA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.0556
p.R46G	DO15535	HNSC	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.1389
p.A36S	DO228938	LICA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.7588
p.C48F	DO228974	LICA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.0833
p.C48F	DO228976	LICA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.0833
p.A38V	DO218900	SKCA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.6936
p.A36V	DO37707	SKCM	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.6936
p.R46W	DO48766	SKCM	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.1389
p.P24Q	DO229163	THCA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.0556
p.C31R	DO229181	THCA	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.25
p.P29S	DO43418	UCEC	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.1944
p.R44Q	DO42504	UCEC	ICGC	NQETGE	DEG_Kelch_Keap1_1	0.6389
p.D31N	HCC-78	lung	COSMIC	NQETGE	DEG_Kelch_Keap1_1	0.25

Drug responses associated with IKBKB mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00839	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	BMS-345541	25.6892
SIDM00839	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	KIN001-260	129.253
SIDM00839	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	TPCA-1	78.7821
SIDM00578	NB\|neuroblastoma	p.R526Q (No)	GDSC	KIN001-260	37.8894
SIDM00578	NB\|neuroblastoma	p.R526Q (No)	GDSC	TPCA-1	26.2438
SIDM01180	LIHC\|liver	p.T344M (No)	GDSC	BMS-345541	17.4082
SIDM01180	LIHC\|liver	p.T344M (No)	GDSC	KIN001-260	9.7868
SIDM01180	LIHC\|liver	p.T344M (No)	GDSC	TPCA-1	20.1551
SIDM00190	SKCM\|melanoma	p.Q611* (No)	GDSC	BMS-345541	19.869
SIDM00190	SKCM\|melanoma	p.Q611* (No)	GDSC	KIN001-260	207.7802
SIDM00190	SKCM\|melanoma	p.Q611* (No)	GDSC	TPCA-1	223.9142
SIDM00951	LAML\|acute_myeloid_leukaemia	p.H284Y (No)	GDSC	BMS-345541	1.3652
SIDM00951	LAML\|acute_myeloid_leukaemia	p.H284Y (No)	GDSC	KIN001-260	19.8325
SIDM00951	LAML\|acute_myeloid_leukaemia	p.H284Y (No)	GDSC	TPCA-1	4.4279
SIDM01031	ESCA\|oesophagus	p.G374S (No)	GDSC	BMS-345541	25.2629
SIDM01031	ESCA\|oesophagus	p.G374S (No)	GDSC	KIN001-260	137.0419
SIDM01031	ESCA\|oesophagus	p.G374S (No)	GDSC	TPCA-1	20.4936
SIDM00498	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	BMS-345541	43.4049
SIDM00498	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	KIN001-260	324.4966
SIDM00498	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	TPCA-1	36.23
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.R526Q (No)	GDSC	BMS-345541	9.692
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.R526Q (No)	GDSC	KIN001-260	19.6576
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.R526Q (No)	GDSC	TPCA-1	8.2657
SIDM00966	OV\|ovary	p.F734L (No)	GDSC	BMS-345541	45.0446
SIDM00966	OV\|ovary	p.F734L (No)	GDSC	KIN001-260	265.4746
SIDM00966	OV\|ovary	p.F734L (No)	GDSC	TPCA-1	59.8041
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S472fs*>12 (No)	GDSC	BMS-345541	3.8379
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S472fs*>12 (No)	GDSC	KIN001-260	12.2264
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.S472fs*>12 (No)	GDSC	TPCA-1	1.0263
SIDM00837	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	BMS-345541	14.5366
SIDM00837	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	KIN001-260	95.9429
SIDM00837	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	TPCA-1	11.851
SIDM00976	SKCM\|melanoma	p.K337N (No)	GDSC	BMS-345541	12.4319
SIDM00976	SKCM\|melanoma	p.K337N (No)	GDSC	KIN001-260	295.7629
SIDM00976	SKCM\|melanoma	p.K337N (No)	GDSC	TPCA-1	213.5216
SIDM00537	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	BMS-345541	19.2409
SIDM00537	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	KIN001-260	68.9431
SIDM00537	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	TPCA-1	16.0041
SIDM01132	MB\|medulloblastoma	p.T344M (No)	GDSC	BMS-345541	9.6535
SIDM01132	MB\|medulloblastoma	p.T344M (No)	GDSC	KIN001-260	98.4944
SIDM01132	MB\|medulloblastoma	p.T344M (No)	GDSC	TPCA-1	17.4552
SIDM00251	STAD\|stomach	p.R55* (No)	GDSC	BMS-345541	27.0304
SIDM00251	STAD\|stomach	p.R55* (No)	GDSC	KIN001-260	90.0696
SIDM00251	STAD\|stomach	p.R55* (No)	GDSC	TPCA-1	103.6547
SIDM00675	BRCA\|breast	p.A360S (No)	GDSC	BMS-345541	30.6106
SIDM00675	BRCA\|breast	p.A360S (No)	GDSC	KIN001-260	89.2912
SIDM00675	BRCA\|breast	p.A360S (No)	GDSC	TPCA-1	28.1041
SIDM00498	COREAD\|large_intestine	p.A710T (No)	GDSC	BMS-345541	43.4049
SIDM00498	COREAD\|large_intestine	p.A710T (No)	GDSC	KIN001-260	324.4966
SIDM00498	COREAD\|large_intestine	p.A710T (No)	GDSC	TPCA-1	36.23
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.R645W (No)	GDSC	BMS-345541	4.3017
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.R645W (No)	GDSC	KIN001-260	12.0106
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.R645W (No)	GDSC	TPCA-1	3.0515
SIDM00602	STAD\|stomach	p.N677D (No)	GDSC	BMS-345541	3.9589
SIDM00602	STAD\|stomach	p.N677D (No)	GDSC	KIN001-260	117.5009
SIDM00602	STAD\|stomach	p.N677D (No)	GDSC	TPCA-1	13.7859
SIDM00946	ALL\|T_cell_leukemia	p.K477N (No)	GDSC	BMS-345541	1.4258
SIDM00946	ALL\|T_cell_leukemia	p.K477N (No)	GDSC	KIN001-260	6.0788
SIDM00946	ALL\|T_cell_leukemia	p.K477N (No)	GDSC	TPCA-1	0.3904
SIDM01193	GBM\|glioma	p.R118W (No)	GDSC	BMS-345541	307.5849
SIDM01193	GBM\|glioma	p.R118W (No)	GDSC	KIN001-260	152.616
SIDM01193	GBM\|glioma	p.R118W (No)	GDSC	TPCA-1	106.1606
SIDM00217	COREAD\|large_intestine	p.R20H (No)	GDSC	BMS-345541	12.3874
SIDM00217	COREAD\|large_intestine	p.R20H (No)	GDSC	KIN001-260	38.3387
SIDM00217	COREAD\|large_intestine	p.R20H (No)	GDSC	TPCA-1	6.5148
SIDM00323	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	BMS-345541	13.263
SIDM00323	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	KIN001-260	42.5367
SIDM00323	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	TPCA-1	5.634
SIDM00243	UNCLASSIFIED\|testis	p.R526Q (No)	GDSC	BMS-345541	5.7484
SIDM00243	UNCLASSIFIED\|testis	p.R526Q (No)	GDSC	KIN001-260	34.4731
SIDM00243	UNCLASSIFIED\|testis	p.R526Q (No)	GDSC	TPCA-1	5.7239
SIDM00665	STAD\|stomach	p.A755V (No)	GDSC	BMS-345541	8.828
SIDM00665	STAD\|stomach	p.A755V (No)	GDSC	KIN001-260	69.6455
SIDM00665	STAD\|stomach	p.A755V (No)	GDSC	TPCA-1	75.6108
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S472fs*>12 (No)	GDSC	BMS-345541	1.3652
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S472fs*>12 (No)	GDSC	KIN001-260	19.8325
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S472fs*>12 (No)	GDSC	TPCA-1	4.4279
SIDM00282	COREAD\|large_intestine	p.M590I (No)	GDSC	BMS-345541	18.9258
SIDM00282	COREAD\|large_intestine	p.M590I (No)	GDSC	KIN001-260	267.7852
SIDM00282	COREAD\|large_intestine	p.M590I (No)	GDSC	TPCA-1	54.1966
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.I413S (No)	GDSC	BMS-345541	26.0004
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.I413S (No)	GDSC	KIN001-260	128.4989
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.I413S (No)	GDSC	TPCA-1	47.6918
SIDM00321	UNCLASSIFIED\|ovary	p.R526Q (No)	GDSC	BMS-345541	77.097
SIDM00321	UNCLASSIFIED\|ovary	p.R526Q (No)	GDSC	KIN001-260	246.3179
SIDM00321	UNCLASSIFIED\|ovary	p.R526Q (No)	GDSC	TPCA-1	113.8193
SIDM00660	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	BMS-345541	6.4259
SIDM00660	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	KIN001-260	111.9512
SIDM00660	COREAD\|large_intestine	p.S472fs*>12 (No)	GDSC	TPCA-1	12.183
SIDM00673	BRCA\|breast	p.P296L (No)	GDSC	BMS-345541	8.6152
SIDM00673	BRCA\|breast	p.P296L (No)	GDSC	KIN001-260	169.0205
SIDM00673	BRCA\|breast	p.P296L (No)	GDSC	TPCA-1	52.9692
SIDM00627	CESC\|cervix	p.S507* (No)	GDSC	BMS-345541	7.9233
SIDM00627	CESC\|cervix	p.S507* (No)	GDSC	KIN001-260	144.0726
SIDM00627	CESC\|cervix	p.S507* (No)	GDSC	TPCA-1	3.78
SIDM00534	COREAD\|large_intestine	p.V327A (No)	GDSC	BMS-345541	189.0119
SIDM00534	COREAD\|large_intestine	p.V327A (No)	GDSC	KIN001-260	266.3095
SIDM00534	COREAD\|large_intestine	p.V327A (No)	GDSC	TPCA-1	160.5032
SIDM01146	STAD\|stomach	p.S472fs*>12 (No)	GDSC	BMS-345541	3.0693
SIDM01146	STAD\|stomach	p.S472fs*>12 (No)	GDSC	KIN001-260	26.2016
SIDM01146	STAD\|stomach	p.S472fs*>12 (No)	GDSC	TPCA-1	17.6206
SIDM00859	DLBC\|B_cell_lymphoma	p.S472fs*>12 (No)	GDSC	BMS-345541	3.8432
SIDM00859	DLBC\|B_cell_lymphoma	p.S472fs*>12 (No)	GDSC	KIN001-260	33.1848
SIDM00859	DLBC\|B_cell_lymphoma	p.S472fs*>12 (No)	GDSC	TPCA-1	4.0071
SIDM00241	BRCA\|breast	p.G685W (No)	GDSC	BMS-345541	12.5987
SIDM00241	BRCA\|breast	p.G685W (No)	GDSC	KIN001-260	55.5923
SIDM00241	BRCA\|breast	p.G685W (No)	GDSC	TPCA-1	7.339
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.T344M (No)	GDSC	BMS-345541	2.5126
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.T344M (No)	GDSC	KIN001-260	118.3986
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.T344M (No)	GDSC	TPCA-1	6.3215
SIDM00254	NB\|neuroblastoma	p.G544R (No)	GDSC	BMS-345541	17.4043
SIDM00254	NB\|neuroblastoma	p.G544R (No)	GDSC	KIN001-260	60.3434
SIDM00254	NB\|neuroblastoma	p.G544R (No)	GDSC	TPCA-1	15.6575
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.Q449R (No)	GDSC	BMS-345541	8.5363
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.Q449R (No)	GDSC	KIN001-260	59.1665
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.Q449R (No)	GDSC	TPCA-1	15.1207
SIDM00364	ALL\|lymphoblastic_leukemia	p.R526Q (No)	GDSC	BMS-345541	9.1593
SIDM00364	ALL\|lymphoblastic_leukemia	p.R526Q (No)	GDSC	KIN001-260	13.0278
SIDM00364	ALL\|lymphoblastic_leukemia	p.R526Q (No)	GDSC	TPCA-1	0.5249
SIDM01259	ALL\|lymphoblastic_leukemia	p.S239T (No)	GDSC	BMS-345541	12.8464
SIDM01259	ALL\|lymphoblastic_leukemia	p.S239T (No)	GDSC	KIN001-260	31.9785
SIDM01259	ALL\|lymphoblastic_leukemia	p.S239T (No)	GDSC	TPCA-1	9.1957
SIDM01259	ALL\|lymphoblastic_leukemia	p.D242N (No)	GDSC	BMS-345541	12.8464
SIDM01259	ALL\|lymphoblastic_leukemia	p.D242N (No)	GDSC	KIN001-260	31.9785
SIDM01259	ALL\|lymphoblastic_leukemia	p.D242N (No)	GDSC	TPCA-1	9.1957
SIDM00374	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	BMS-345541	1.5875
SIDM00374	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	KIN001-260	12.4972
SIDM00374	DLBC\|B_cell_lymphoma	p.R526Q (No)	GDSC	TPCA-1	3.4237
SIDM00333	UCEC\|endometrium	p.S472fs*>12 (No)	GDSC	BMS-345541	9.4579
SIDM00333	UCEC\|endometrium	p.S472fs*>12 (No)	GDSC	KIN001-260	224.9691
SIDM00333	UCEC\|endometrium	p.S472fs*>12 (No)	GDSC	TPCA-1	133.0159
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.D90N (No)	GDSC	BMS-345541	6.1914
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.D90N (No)	GDSC	KIN001-260	316.9389
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.D90N (No)	GDSC	TPCA-1	21.5335
SIDM00878	BRCA\|breast	p.Y199C (No)	GDSC	BMS-345541	24.5116
SIDM00878	BRCA\|breast	p.Y199C (No)	GDSC	KIN001-260	187.7028
SIDM00878	BRCA\|breast	p.Y199C (No)	GDSC	TPCA-1	40.2262
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.757 (No)	GDSC	BMS-345541	136.8092
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.757 (No)	GDSC	KIN001-260	394.8836
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.757 (No)	GDSC	TPCA-1	619.5913
SIDM00193	COREAD\|large_intestine	p.R526Q (No)	GDSC	BMS-345541	26.5606
SIDM00193	COREAD\|large_intestine	p.R526Q (No)	GDSC	KIN001-260	520.5735
SIDM00193	COREAD\|large_intestine	p.R526Q (No)	GDSC	TPCA-1	373.5889
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.R526Q (No)	GDSC	BMS-345541	16.9536
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.R526Q (No)	GDSC	KIN001-260	305.4805
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.R526Q (No)	GDSC	TPCA-1	109.4089

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NQETGE

Degron related mutations and impact score

Drug responses associated with IKBKB mutations

All proteins holding degron of NQETGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	DEG_Kelch_Keap1_1	34:39	NQETGE	KEAP1	0.9774	More...