DegronMD

Uniprot ID: P53350

Source protein: Serine/threonine-protein kinase PLK1

Source gene: PLK1

Class: DEG_APCC_DBOX_1

Location: 336:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 81.1778

COIL: 0.7378

CONS_SCORE: 0.3555

DSS_SCORE: 0.5442

HELIX: 0.1386

FCONS_SCORE: 1.3974

RIG_SCORE: 0.6926

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S335C	TCGA-38-4625	LUAD	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S335C	DO23952	LUAD	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S326L	TCGA-3N-A9WC	SKCM	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	TCGA-AG-A002	READ	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	TCGA-AP-A1DV	UCEC	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	TCGA-EE-A3JB	SKCM	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	TCGA-ER-A2NH	SKCM	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO222884	COCA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO222696	MELA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO47683	SKCM	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO51250	SKCM	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO51234	SKCM	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	DO43186	UCEC	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	SIDM01611	Endometrial Carcinoma	GDSC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.S326L	ACH-000996	Endometrial/Uterine Cancer	CCLE	NRKPLTVLN	DEG_APCC_DBOX_1	0.5
p.R337W	TCGA-A5-A0G1	UCEC	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.8634
p.R337W	TCGA-BR-4280	STAD	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.8634
p.R337W	DO227686	COCA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.8634
p.R337W	DO38663	STAD	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.8634
p.R337W	DO42472	UCEC	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.8634
p.T341I	TCGA-A5-A0GA	UCEC	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.7078
p.T341I	DO43763	UCEC	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.7078
p.V342F	TCGA-EO-A22U	UCEC	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.5957
p.V342F	DO43755	UCEC	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.5957
p.R354C	TCGA-VQ-A91K	STAD	TCGA	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354C	DO51785	STAD	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	DO230346	COCA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	DO227979	COCA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	DO233168	GACA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	SIDM00611	Kidney Carcinoma	GDSC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	SIDM00214	Colorectal Carcinoma	GDSC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	SIDM00549	B-Lymphoblastic Leukemia	GDSC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	EBC-1	lung	COSMIC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	KMRC-1	kidney	COSMIC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.R354H	SNU-407	large_intestine	COSMIC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0556
p.D333Y	DO228948	LICA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.25
p.I327V	DO229061	LICA	ICGC	NRKPLTVLN	DEG_APCC_DBOX_1	0.0833
p.S335R	ACH-000398	Lymphoma	CCLE	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S335R	ACH-001022	Bone Cancer	CCLE	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S335R	ACH-001454	Colon/Colorectal Cancer	CCLE	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S335R	ACH-002144	Lung Cancer	CCLE	NRKPLTVLN	DEG_APCC_DBOX_1	0.75
p.S335R	IST-SL1	lung	COSMIC	NRKPLTVLN	DEG_APCC_DBOX_1	0.75

Drug responses associated with PLK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (Yes)	GDSC	BI-2536	0.1445
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (Yes)	GDSC	GW843682X	0.1045
SIDM00223	SCLC\|lung_small_cell_carcinoma	p.S335R (Yes)	GDSC	PLK_6522	0.4695
SIDM01164	LGG\|glioma	p.A520T (No)	GDSC	MK-1775	1.1087
SIDM00826	COREAD\|large_intestine	p.K601N (No)	GDSC	PLK_6522	0.6758
SIDM00826	COREAD\|large_intestine	p.K601N (No)	GDSC	MK-1775	1.3839
SIDM00797	SKCM\|melanoma	p.P355S (Yes)	GDSC	MK-1775	1.0078
SIDM00980	STAD\|stomach	p.Q242P (No)	GDSC	PLK_6522	0.0359
SIDM00980	STAD\|stomach	p.Q242P (No)	GDSC	MK-1775	0.8649
SIDM00214	COREAD\|large_intestine	p.R354H (Yes)	GDSC	PLK_6522	0.0315
SIDM00214	COREAD\|large_intestine	p.R354H (Yes)	GDSC	MK-1775	1.4325
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	BI-2536	0.3011
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	GW843682X	0.1448
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	PLK_6522	1.6712
SIDM00239	KIRC\|kidney	p.E568* (No)	GDSC	MK-1775	27.949
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	BI-2536	0.0173
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	GW843682X	0.0082
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	PLK_6522	0.0078
SIDM00441	LAML\|acute_myeloid_leukaemia	p.Y421* (No)	GDSC	MK-1775	0.3416
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R354H (Yes)	GDSC	PLK_6522	0.0682
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R354H (Yes)	GDSC	MK-1775	7.7584
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	BI-2536	0.0222
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	GW843682X	0.0165
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	PLK_6522	0.0325
SIDM00369	ESCA\|oesophagus	p.S224R (No)	GDSC	MK-1775	1.3274
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	BI-2536	0.2057
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	GW843682X	0.0729
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	PLK_6522	0.0945
SIDM00056	THCA\|thyroid	p.P229S (No)	GDSC	MK-1775	5.4403
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	BI-2536	0.028
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	GW843682X	0.0159
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	PLK_6522	0.0414
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.T306S (No)	GDSC	MK-1775	0.3487
SIDM00217	COREAD\|large_intestine	p.R441C (No)	GDSC	PLK_6522	1.7973
SIDM00217	COREAD\|large_intestine	p.R441C (No)	GDSC	MK-1775	1.0304
SIDM00140	SKCM\|melanoma	p.K265* (No)	GDSC	PLK_6522	0.1346
SIDM00140	SKCM\|melanoma	p.K265* (No)	GDSC	MK-1775	8.9573
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	BI-2536	0.0928
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	GW843682X	0.0444
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	PLK_6522	0.0142
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.I296V (No)	GDSC	MK-1775	0.3342
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.W410R (No)	GDSC	PLK_6522	0.026
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.W410R (No)	GDSC	MK-1775	0.3277
SIDM01096	COREAD\|large_intestine	p.Q283* (No)	GDSC	PLK_6522	0.0423
SIDM01096	COREAD\|large_intestine	p.Q283* (No)	GDSC	MK-1775	0.6997
SIDM00596	UCEC\|endometrium	p.R169* (No)	GDSC	PLK_6522	0.2797
SIDM00596	UCEC\|endometrium	p.R169* (No)	GDSC	MK-1775	2.7894
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	BI-2536	0.0143
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	GW843682X	0.0109
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	PLK_6522	0.3194
SIDM00150	COREAD\|large_intestine	p.S375G (No)	GDSC	MK-1775	0.413
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	BI-2536	0.0177
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	GW843682X	0.0063
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	PLK_6522	0.2393
SIDM00660	COREAD\|large_intestine	p.P151S (No)	GDSC	MK-1775	0.6095
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	BI-2536	0.0177
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	GW843682X	0.0063
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	PLK_6522	0.2393
SIDM00660	COREAD\|large_intestine	p.R500H (No)	GDSC	MK-1775	0.6095
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.S595L (No)	GDSC	PLK_6522	0.032
SIDM00903	LUAD\|lung_NSCLC_adenocarcinoma	p.S595L (No)	GDSC	MK-1775	3.1719
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	BI-2536	0.0905
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	GW843682X	0.0503
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	PLK_6522	0.0282
SIDM00257	NB\|neuroblastoma	p.N297D (No)	GDSC	MK-1775	0.8099
SIDM00487	COREAD\|large_intestine	p.V587delV (No)	GDSC	PLK_6522	0.1707
SIDM00487	COREAD\|large_intestine	p.V587delV (No)	GDSC	MK-1775	0.4067
SIDM00379	GBM\|glioma	p.L261fs*60 (No)	GDSC	PLK_6522	0.0231
SIDM00379	GBM\|glioma	p.L261fs*60 (No)	GDSC	MK-1775	2.1473
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	BI-2536	0.2848
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	GW843682X	0.266
SIDM00255	NB\|neuroblastoma	p.P250H (No)	GDSC	PLK_6522	0.0677
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.R364Q (No)	GDSC	PLK_6522	0.094
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.R364Q (No)	GDSC	MK-1775	0.5255
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (Yes)	GDSC	BI-2536	0.1372
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (Yes)	GDSC	GW843682X	0.0477
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (Yes)	GDSC	PLK_6522	0.0989
SIDM00549	ALL\|lymphoblastic_leukemia	p.R354H (Yes)	GDSC	MK-1775	0.3687
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	BI-2536	0.4894
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	GW843682X	0.1977
SIDM00254	NB\|neuroblastoma	p.N297D (No)	GDSC	PLK_6522	0.0601
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	PLK_6522	0.0219
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	BI-2536	4.4982
SIDM00528	BRCA\|breast	p.Q426* (No)	GDSC	MK-1775	3.2182
SIDM00444	ESCA\|oesophagus	p.R557W (No)	GDSC	PLK_6522	0.5422
SIDM00444	ESCA\|oesophagus	p.R557W (No)	GDSC	MK-1775	0.9648
SIDM00611	KIRC\|kidney	p.R354H (Yes)	GDSC	PLK_6522	0.3272
SIDM00611	KIRC\|kidney	p.R354H (Yes)	GDSC	MK-1775	15.688
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	BI-2536	0.0311
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	GW843682X	0.0298
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	PLK_6522	0.0888
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.K178* (No)	GDSC	MK-1775	54.604
SIDM00537	COREAD\|large_intestine	p.G238W (No)	GDSC	PLK_6522	0.0263
SIDM00537	COREAD\|large_intestine	p.G238W (No)	GDSC	MK-1775	0.7137
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	PLK_6522	9.8996
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	BI-2536	18.254
SIDM00892	BRCA\|breast	p.F125L (No)	GDSC	MK-1775	149.22
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	BI-2536	0.7804
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	GW843682X	0.4615
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	PLK_6522	0.0161
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.L286F (No)	GDSC	MK-1775	0.9944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRKPLTVLN

Degron related mutations and impact score

Drug responses associated with PLK1 mutations

All proteins holding degron of NRKPLTVLN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53350	Serine/threonine-protein kinase PLK1	DEG_APCC_DBOX_1	336:344	NRKPLTVLN	APC,CDC20,FZR1	0.9995	More...