DegronMD

Uniprot ID: Q9Y572

Source protein: Receptor-interacting serine/threonine-protein kinase 3

Source gene: RIPK3

Class: DEG_APCC_DBOX_1

Location: 238:246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8986

ASA_SCORE: 60.4889

COIL: 0.8107

CONS_SCORE: 0.3784

DSS_SCORE: 0.5031

HELIX: 0.1328

FCONS_SCORE: 1.0281

RIG_SCORE: 0.7021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R239W	TCGA-AX-A3FT	UCEC	TCGA	NRPSLAELP	DEG_APCC_DBOX_1	0.8634
p.R239W	DO40801	UCEC	ICGC	NRPSLAELP	DEG_APCC_DBOX_1	0.8634
p.Q237K	TCGA-D8-A1XK	BRCA	TCGA	NRPSLAELP	DEG_APCC_DBOX_1	0.3056
p.Q237K	DO4749	BRCA	ICGC	NRPSLAELP	DEG_APCC_DBOX_1	0.3056
p.E231K	TCGA-F5-6814	READ	TCGA	NRPSLAELP	DEG_APCC_DBOX_1	0.1389
p.E231K	DO36556	READ	ICGC	NRPSLAELP	DEG_APCC_DBOX_1	0.1389
p.R239Q	SIDM02049	Pancreatic Carcinoma	GDSC	NRPSLAELP	DEG_APCC_DBOX_1	0.7329
p.R239Q	SIDM00454	Rhabdomyosarcoma	GDSC	NRPSLAELP	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	238:246	NRPSLAELP	APC,CDC20,FZR1	0.8986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons