DegronMD

Uniprot ID: P08238

Source protein: Heat shock protein HSP 90-beta

Source gene: HSP90AB1

Class: DEG_APCC_DBOX_1

Location: 447:455

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.725

ASA_SCORE: 49.0444

COIL: 0.0469

CONS_SCORE: 0.5679

DSS_SCORE: 0.4104

HELIX: 0.949

FCONS_SCORE: 1.0083

RIG_SCORE: 0.762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R449H	TCGA-2W-A8YY	CESC	TCGA	NRRRLSELL	DEG_APCC_DBOX_1	0.7133
p.R449H	DO223732	CESC	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.7133
p.R449H	DO233746	GACA	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.7133
p.R448H	TCGA-CR-6478	HNSC	TCGA	NRRRLSELL	DEG_APCC_DBOX_1	0.8244
p.R448H	DO233855	GACA	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.8244
p.R448H	DO15839	HNSC	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.8244
p.R448C	TCGA-D7-A6EV	STAD	TCGA	NRRRLSELL	DEG_APCC_DBOX_1	0.8301
p.R448C	DO50116	STAD	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.8301
p.R456L	TCGA-E2-A1IJ	BRCA	TCGA	NRRRLSELL	DEG_APCC_DBOX_1	0.3056
p.R456L	DO2761	BRCA	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.3056
p.Q461H	DO229041	LICA	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.1667
p.Y457C	DO48888	PBCA	ICGC	NRRRLSELL	DEG_APCC_DBOX_1	0.7222
p.R450H	SIDM01307	Colorectal Carcinoma	GDSC	NRRRLSELL	DEG_APCC_DBOX_1	0.7133
p.E443K	SIDM00118	Colorectal Carcinoma	GDSC	NRRRLSELL	DEG_APCC_DBOX_1	0.2222
p.E443K	ACH-001081	Colon/Colorectal Cancer	CCLE	NRRRLSELL	DEG_APCC_DBOX_1	0.2222
p.E443K	HCC2998	large_intestine	COSMIC	NRRRLSELL	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08238	Heat shock protein HSP 90-beta	DEG_APCC_DBOX_1	447:455	NRRRLSELL	APC,CDC20,FZR1	0.725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons