DegronMD

Uniprot ID: P43403

Source protein: Tyrosine-protein kinase ZAP-70

Source gene: ZAP70

Class: CBL_PTK

Location: 288:296

E3 ligase: CBL

DEGRON score: 0.9992

ASA_SCORE: 74.6111

COIL: 0.8772

CONS_SCORE: 0.5112

DSS_SCORE: 0.7235

HELIX: 0.0554

FCONS_SCORE: 1.3665

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D303G	TCGA-23-1027	OV	TCGA	NSDGYTPEP	CBL_PTK	0.1389
p.D303G	DO30540	OV	ICGC	NSDGYTPEP	CBL_PTK	0.1389
p.H279P	TCGA-A5-A0G1	UCEC	TCGA	NSDGYTPEP	CBL_PTK	0.0833
p.R306W	TCGA-DF-A2KN	UCEC	TCGA	NSDGYTPEP	CBL_PTK	0.0556
p.R306W	DO223282	UCEC	ICGC	NSDGYTPEP	CBL_PTK	0.0556
p.D303N	TCGA-QC-A7B5	SARC	TCGA	NSDGYTPEP	CBL_PTK	0.1389
p.D303N	DO220239	SARC	ICGC	NSDGYTPEP	CBL_PTK	0.1389
p.T300M	DO233276	GACA	ICGC	NSDGYTPEP	CBL_PTK	0.6667
p.T300M	DO228338	MALY	ICGC	NSDGYTPEP	CBL_PTK	0.6667
p.T300M	SIDM00948	Burkitt's Lymphoma	GDSC	NSDGYTPEP	CBL_PTK	0.6667
p.T300M	ACH-002232	Lymphoma	CCLE	NSDGYTPEP	CBL_PTK	0.6667
p.T300M	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	NSDGYTPEP	CBL_PTK	0.6667
p.G291E	SIDM00545	Melanoma	GDSC	NSDGYTPEP	CBL_PTK	0.6087
p.G291E	ACH-000987	Skin Cancer	CCLE	NSDGYTPEP	CBL_PTK	0.6087
p.G291E	Mewo	skin	COSMIC	NSDGYTPEP	CBL_PTK	0.6087
p.D285N	SIDM00217	Colorectal Carcinoma	GDSC	NSDGYTPEP	CBL_PTK	0.25
p.D285N	ACH-000999	Colon/Colorectal Cancer	CCLE	NSDGYTPEP	CBL_PTK	0.25
p.D285N	SNU-1040	large_intestine	COSMIC	NSDGYTPEP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43403	Tyrosine-protein kinase ZAP-70	CBL_PTK	288:296	NSDGYTPEP	CBL	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons