DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NSPMWYSTFP
Uniprot ID:
Q5VZL5
Source protein:
Zinc finger MYM-type protein 4
Source gene:
ZMYM4
Class:
CBL_PTK
Location:
1502:1511
E3 ligase:
CBL
DEGRON score:
0.9325
ASA_SCORE:
66.79
COIL:
0.6781
CONS_SCORE:
0.7058
DSS_SCORE:
0.273
HELIX:
0.0264
FCONS_SCORE:
1.2443
RIG_SCORE:
0.7765
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1501L
TCGA-A5-A1OF
UCEC
TCGA
NSPMWYSTFP
CBL_PTK
0.3056
p.S1503I
TCGA-B5-A3FA
UCEC
TCGA
NSPMWYSTFP
CBL_PTK
0.623
p.R1497H
TCGA-FA-A82F
DLBC
TCGA
NSPMWYSTFP
CBL_PTK
0.1944
p.R1497H
SIDM00151
Ovarian Carcinoma
GDSC
NSPMWYSTFP
CBL_PTK
0.1944
p.T1519A
TCGA-FD-A6TG
BLCA
TCGA
NSPMWYSTFP
CBL_PTK
0.1111
p.R1497C
TCGA-HU-A4GX
STAD
TCGA
NSPMWYSTFP
CBL_PTK
0.1944
p.R1497C
SIDM00878
Breast Carcinoma
GDSC
NSPMWYSTFP
CBL_PTK
0.1944
p.R1497C
ACH-000930
Breast Cancer
CCLE
NSPMWYSTFP
CBL_PTK
0.1944
p.R1497C
HCC1569
breast
COSMIC
NSPMWYSTFP
CBL_PTK
0.1944
Drug responses associated with ZMYM4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSPMWYSTFP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VZL5
Zinc finger MYM-type protein 4
CBL_PTK
1502:1511
NSPMWYSTFP
CBL
0.9325
More...
