DegronMD

Uniprot ID: P17948

Source protein: Vascular endothelial growth factor receptor 1

Source gene: FLT1

Class: CBL_PTK

Location: 1328:1337

E3 ligase: CBL

DEGRON score: 0.9994

ASA_SCORE: 78.57

COIL: 0.8551

CONS_SCORE: 0.3897

DSS_SCORE: 0.532

HELIX: 0.0353

FCONS_SCORE: 0.978

RIG_SCORE: 0.7814

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1338M	TCGA-28-5207	GBM	TCGA	NSVVLYSTPP	CBL_PTK	0.3056
p.A1319T	TCGA-A5-A0G1	UCEC	TCGA	NSVVLYSTPP	CBL_PTK	0.0833
p.A1319T	ACH-001143	Lymphoma	CCLE	NSVVLYSTPP	CBL_PTK	0.0833
p.I1318T	TCGA-CV-A461	HNSC	TCGA	NSVVLYSTPP	CBL_PTK	0.0556
p.P1337A	SIDM00502	B-Lymphoblastic Leukemia	GDSC	NSVVLYSTPP	CBL_PTK	0.7503
p.P1337A	ACH-000157	Lymphoma	CCLE	NSVVLYSTPP	CBL_PTK	0.7503
p.P1337A	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	NSVVLYSTPP	CBL_PTK	0.7503

Drug responses associated with FLT1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Midostaurin	0.4665
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Cabozantinib	54.4797
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Linifanib	4.1781
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Tivozanib	2.0097
SIDM00554	UNCLASSIFIED\|ovary	p.L563W (No)	GDSC	Cediranib	81.07
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Midostaurin	0.9871
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Cabozantinib	4.964
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Linifanib	6.3378
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Tivozanib	0.2649
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.T568M (No)	GDSC	Cediranib	5.6412
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Midostaurin	2.2885
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Cabozantinib	6.7173
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Linifanib	11.0972
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Tivozanib	1.3668
SIDM00889	CESC\|cervix	p.K1153fs*2 (No)	GDSC	Cediranib	6.5884
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Midostaurin	0.6754
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Cabozantinib	74.3509
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Linifanib	12.5688
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Tivozanib	1.5352
SIDM00839	COREAD\|large_intestine	p.K171fs*7 (No)	GDSC	Cediranib	3.5062
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Midostaurin	0.2602
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Cabozantinib	17.394
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Linifanib	10.1914
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Tivozanib	1.4202
SIDM01031	ESCA\|oesophagus	p.A769V (No)	GDSC	Cediranib	6.0808
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Midostaurin	0.1558
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Cabozantinib	13.4877
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Linifanib	8.8383
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Tivozanib	1.39
SIDM00826	COREAD\|large_intestine	p.R280* (No)	GDSC	Cediranib	5.736
SIDM00981	DLBC\|B_cell_lymphoma	p.S1277N (No)	GDSC	Midostaurin	0.7545
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Midostaurin	0.9804
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Cabozantinib	17.0263
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Linifanib	27.0999
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Tivozanib	2.2397
SIDM01032	ESCA\|oesophagus	p.K116T (No)	GDSC	Cediranib	4.8151
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Midostaurin	5.707
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Linifanib	5.6349
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Tivozanib	1.1711
SIDM00683	PRAD\|prostate	p.S62P (No)	GDSC	Cediranib	8.4465
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Midostaurin	6.4387
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cabozantinib	33.5864
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Linifanib	8.2605
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Tivozanib	2.431
SIDM00272	BRCA\|breast	p.S788F (No)	GDSC	Cediranib	13.538
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Midostaurin	0.6714
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Cabozantinib	25.621
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Linifanib	11.8566
SIDM01051	UNCLASSIFIED\|ovary	p.R1045Q (No)	GDSC	Tivozanib	2.5587
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Midostaurin	1.5394
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Cabozantinib	9.767
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Linifanib	12.4528
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Tivozanib	1.4308
SIDM00980	STAD\|stomach	p.E982A (No)	GDSC	Cediranib	5.3843
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Midostaurin	0.175
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Cabozantinib	14.3579
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Linifanib	9.6552
SIDM00666	LGG\|glioma	p.E689K (No)	GDSC	Tivozanib	0.8847
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R1257H (No)	GDSC	Cediranib	1.5274
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Midostaurin	0.6669
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Cabozantinib	36.3311
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Linifanib	8.2801
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Tivozanib	0.5535
SIDM00220	OV\|ovary	p.R1114S (No)	GDSC	Cediranib	4.4919
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Midostaurin	4.472
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Cabozantinib	5.8082
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Linifanib	17.9385
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Tivozanib	1.3661
SIDM00003	SKCM\|melanoma	p.R781Q (No)	GDSC	Cediranib	6.3731
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Midostaurin	0.8548
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Cabozantinib	4.9456
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Linifanib	2.1076
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Tivozanib	0.2813
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.C1039S (No)	GDSC	Cediranib	5.8297
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Midostaurin	0.6198
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Cabozantinib	27.0342
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Linifanib	9.9664
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Tivozanib	1.4206
SIDM00551	ESCA\|oesophagus	p.W820* (No)	GDSC	Cediranib	5.3205
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Midostaurin	0.2459
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Cabozantinib	5.8396
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Linifanib	6.4301
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Tivozanib	1.6521
SIDM00532	LGG\|glioma	p.V960I (No)	GDSC	Cediranib	2.7741
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Midostaurin	0.2189
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Cabozantinib	4.7936
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Linifanib	10.191
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Tivozanib	1.2085
SIDM01066	SKCM\|melanoma	p.S437L (No)	GDSC	Cediranib	8.8365
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Midostaurin	0.6331
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Cabozantinib	52.6341
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Linifanib	12.797
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Tivozanib	1.735
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.I291V (No)	GDSC	Cediranib	8.9193
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Midostaurin	0.7932
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Linifanib	10.7273
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Tivozanib	1.4343
SIDM00333	UCEC\|endometrium	p.T654A (No)	GDSC	Cediranib	5.4692
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Midostaurin	1.3786
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Cabozantinib	13.5361
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Linifanib	3.4172
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Tivozanib	1.0502
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R159L (No)	GDSC	Cediranib	2.9341
SIDM00687	STAD\|stomach	p.Q1243K (No)	GDSC	Cediranib	0.6944
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Linifanib	18.1376
SIDM00217	COREAD\|large_intestine	p.R183H (No)	GDSC	Tivozanib	2.681
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Midostaurin	0.2177
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Cabozantinib	14.1681
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Linifanib	13.9475
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Tivozanib	0.9517
SIDM01199	LIHC\|liver	p.E789K (No)	GDSC	Cediranib	7.1641
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Midostaurin	1.4879
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Linifanib	13.2855
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Tivozanib	1.0314
SIDM00660	COREAD\|large_intestine	p.A376V (No)	GDSC	Cediranib	11.404
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Midostaurin	0.3009
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Cabozantinib	32.0867
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Linifanib	9.9063
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Tivozanib	0.7059
SIDM00567	MB\|medulloblastoma	p.E973K (No)	GDSC	Cediranib	10.273
SIDM01147	STAD\|stomach	p.S752L (No)	GDSC	Cediranib	30.809
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Midostaurin	0.2332
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Cabozantinib	7.227
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Linifanib	5.9157
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Tivozanib	0.7436
SIDM00783	COREAD\|large_intestine	p.R312H (No)	GDSC	Cediranib	6.4073
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Midostaurin	1.6137
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cabozantinib	37.461
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Linifanib	11.3311
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Tivozanib	1.5913
SIDM00673	BRCA\|breast	p.I623M (No)	GDSC	Cediranib	28.435
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Midostaurin	0.2969
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Cabozantinib	8.2222
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Linifanib	4.2589
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Tivozanib	0.7205
SIDM00125	KIRC\|kidney	p.V960I (No)	GDSC	Cediranib	3.5639
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Midostaurin	1.2938
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Cabozantinib	2.7944
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Linifanib	7.9397
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Tivozanib	0.1867
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.M509V (No)	GDSC	Cediranib	4.0338
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Midostaurin	0.4118
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Linifanib	13.547
SIDM00534	COREAD\|large_intestine	p.S62F (No)	GDSC	Tivozanib	1.7085
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Midostaurin	3.3946
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Cabozantinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Linifanib	41.3801
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Tivozanib	4.3501
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R1021Q (No)	GDSC	Cediranib	138.91
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Midostaurin	4.6295
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Cabozantinib	40.284
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Linifanib	12.6652
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Tivozanib	1.7957
SIDM00487	COREAD\|large_intestine	p.V1214A (No)	GDSC	Cediranib	2.6753
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Midostaurin	12.6442
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Cabozantinib	55.7164
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Linifanib	26.1518
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Tivozanib	2.4116
SIDM00282	COREAD\|large_intestine	p.I881fs*13 (No)	GDSC	Cediranib	11.404
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Midostaurin	0.4307
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Cabozantinib	19.7098
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Linifanib	6.0444
SIDM00392	SKCM\|melanoma	p.E982A (No)	GDSC	Tivozanib	2.0587
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Linifanib	18.1376
SIDM00217	COREAD\|large_intestine	p.M566fs*8 (No)	GDSC	Tivozanib	2.681
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (Yes)	GDSC	Midostaurin	0.4196
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (Yes)	GDSC	Cabozantinib	4.8655
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (Yes)	GDSC	Linifanib	11.8845
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (Yes)	GDSC	Tivozanib	1.2883
SIDM00502	DLBC\|B_cell_lymphoma	p.P1337A (Yes)	GDSC	Cediranib	2.9029
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Midostaurin	2.816
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Cabozantinib	34.3229
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Linifanib	14.0756
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Tivozanib	1.0736
SIDM01112	UNCLASSIFIED\|bone_other	p.N425H (No)	GDSC	Cediranib	4.877
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.S1190F (No)	GDSC	Cediranib	9.5587
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.P460S (No)	GDSC	Cediranib	9.5587
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Midostaurin	6.5133
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Linifanib	18.6537
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Tivozanib	2.2473
SIDM00545	SKCM\|melanoma	p.E33K (No)	GDSC	Cediranib	9.5587
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Midostaurin	0.1437
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Cabozantinib	46.186
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Linifanib	18.5427
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Tivozanib	2.3183
SIDM00569	UNCLASSIFIED\|osteosarcoma	p.I391L (No)	GDSC	Cediranib	3.9128
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Midostaurin	0.5691
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Cabozantinib	36.0912
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Linifanib	3.4786
SIDM00733	SCLC\|lung_small_cell_carcinoma	p.N596S (No)	GDSC	Tivozanib	0.877
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Midostaurin	0.5968
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Cabozantinib	19.4136
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Linifanib	10.6073
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Tivozanib	1.5361
SIDM01151	LIHC\|liver	p.E201D (No)	GDSC	Cediranib	25.996
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Midostaurin	1.8701
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Cabozantinib	4.5532
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Linifanib	10.0417
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Tivozanib	2.2374
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.E992K (No)	GDSC	Cediranib	93.26
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Midostaurin	1.8701
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Cabozantinib	4.5532
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Linifanib	10.0417
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Tivozanib	2.2374
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.A111S (No)	GDSC	Cediranib	93.26
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Midostaurin	0.6542
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Cabozantinib	6.6108
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Linifanib	13.4172
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Tivozanib	1.6768
SIDM00373	UCEC\|endometrium	p.V960I (No)	GDSC	Cediranib	5.1694
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Midostaurin	0.331
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Cabozantinib	63.4851
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Linifanib	15.3008
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Tivozanib	2.0611
SIDM00120	PRAD\|prostate	p.L583fs*42 (No)	GDSC	Cediranib	86.136
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Midostaurin	14.6277
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Cabozantinib	374.684
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Linifanib	52.4861
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Tivozanib	8.7495
SIDM00834	COREAD\|large_intestine	p.E984* (No)	GDSC	Cediranib	10.369
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Midostaurin	1.677
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cabozantinib	79.8364
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Linifanib	16.1299
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Tivozanib	2.0243
SIDM00135	BRCA\|breast	p.C1018Y (No)	GDSC	Cediranib	2.468
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Midostaurin	0.3184
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Cabozantinib	51.1254
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Linifanib	24.6252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Tivozanib	2.5741
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A434D (No)	GDSC	Cediranib	18.416
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Midostaurin	3.1483
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Cabozantinib	65.8693
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Linifanib	20.7769
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Tivozanib	2.5628
SIDM00684	GBM\|glioma	p.P143S (No)	GDSC	Cediranib	66.142
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Midostaurin	0.3676
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Cabozantinib	18.8192
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Linifanib	9.1717
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Tivozanib	1.8907
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.S1282L (No)	GDSC	Cediranib	24.911
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Midostaurin	7.5497
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cabozantinib	267.6604
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Linifanib	32.0276
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Tivozanib	6.3583
SIDM00892	BRCA\|breast	p.D987E (No)	GDSC	Cediranib	191.15
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Midostaurin	0.1551
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Cabozantinib	10.026
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Linifanib	0.4296
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Tivozanib	1.8145
SIDM00837	COREAD\|large_intestine	p.D1052N (No)	GDSC	Cediranib	2.8576
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Midostaurin	0.7932
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Linifanib	10.7273
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Tivozanib	1.4343
SIDM00333	UCEC\|endometrium	p.M609fs*5 (No)	GDSC	Cediranib	5.4692
SIDM00238	OV\|ovary	p.A673V (No)	GDSC	Cabozantinib	99.6708
SIDM00238	OV\|ovary	p.A673V (No)	GDSC	Linifanib	17.4035
SIDM00238	OV\|ovary	p.A673V (No)	GDSC	Tivozanib	2.6511
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Midostaurin	0.9826
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Cabozantinib	7.319
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Linifanib	15.6177
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Tivozanib	1.0384
SIDM00416	DLBC\|B_cell_lymphoma	p.A80G (No)	GDSC	Cediranib	4.6927
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Midostaurin	9.6608
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Cabozantinib	3.1184
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Linifanib	16.0025
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Tivozanib	2.0618
SIDM00332	BRCA\|breast	p.G514V (No)	GDSC	Cediranib	1.7237
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Midostaurin	1.7165
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cabozantinib	32.8868
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Linifanib	8.1207
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Tivozanib	1.8598
SIDM00693	BLCA\|bladder	p.L1061V (No)	GDSC	Cediranib	147.05
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Linifanib	15.5526
SIDM00193	COREAD\|large_intestine	p.V721A (No)	GDSC	Tivozanib	1.8904
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Midostaurin	2.9471
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Linifanib	12.9878
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Tivozanib	1.6445
SIDM00118	COREAD\|large_intestine	p.F847V (No)	GDSC	Cediranib	5.8015
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Midostaurin	2.9471
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Linifanib	12.9878
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Tivozanib	1.6445
SIDM00118	COREAD\|large_intestine	p.R314M (No)	GDSC	Cediranib	5.8015

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSVVLYSTPP

Degron related mutations and impact score

Drug responses associated with FLT1 mutations

All proteins holding degron of NSVVLYSTPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17948	Vascular endothelial growth factor receptor 1	CBL_PTK	1328:1337	NSVVLYSTPP	CBL	0.9994	More...