DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NTFLYTGNP
Uniprot ID:
P21589
Source protein:
5'-nucleotidase
Source gene:
NT5E
Class:
CBL_PTK
Location:
245:253
E3 ligase:
CBL
DEGRON score:
0.9786
ASA_SCORE:
47.0889
COIL:
0.8444
CONS_SCORE:
0.3197
DSS_SCORE:
0.3832
HELIX:
0.0816
FCONS_SCORE:
0.7179
RIG_SCORE:
0.7493
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V239M
TCGA-21-1083
LUSC
TCGA
NTFLYTGNP
CBL_PTK
0.1667
p.V239M
DO26769
LUSC
ICGC
NTFLYTGNP
CBL_PTK
0.1667
p.Y263F
TCGA-22-5489
LUSC
TCGA
NTFLYTGNP
CBL_PTK
0.0556
p.Y263F
DO26480
LUSC
ICGC
NTFLYTGNP
CBL_PTK
0.0556
p.A260T
TCGA-FD-A3NA
BLCA
TCGA
NTFLYTGNP
CBL_PTK
0.1389
p.A260T
DO602
BLCA
ICGC
NTFLYTGNP
CBL_PTK
0.1389
p.G235S
TCGA-FW-A3R5
SKCM
TCGA
NTFLYTGNP
CBL_PTK
0.0556
p.G235S
DO37406
SKCM
ICGC
NTFLYTGNP
CBL_PTK
0.0556
p.K262N
DO228952
LICA
ICGC
NTFLYTGNP
CBL_PTK
0.5278
p.A258G
DO228879
LICA
ICGC
NTFLYTGNP
CBL_PTK
0.1944
p.A260S
DO229019
LICA
ICGC
NTFLYTGNP
CBL_PTK
0.1389
p.G241V
DO224544
LUSC
ICGC
NTFLYTGNP
CBL_PTK
0.2222
p.G241V
DO231014
LUSC
ICGC
NTFLYTGNP
CBL_PTK
0.2222
p.R256K
DO38123
SKCM
ICGC
NTFLYTGNP
CBL_PTK
0.3611
p.A258T
DO41331
UCEC
ICGC
NTFLYTGNP
CBL_PTK
0.1944
p.Y263H
SIDM01169
Ovarian Carcinoma
GDSC
NTFLYTGNP
CBL_PTK
0.0556
p.Y263H
ACH-000885
Ovarian Cancer
CCLE
NTFLYTGNP
CBL_PTK
0.0556
p.Y263H
TOV-21G
ovary
COSMIC
NTFLYTGNP
CBL_PTK
0.0556
Drug responses associated with NT5E mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NTFLYTGNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P21589
5'-nucleotidase
CBL_PTK
245:253
NTFLYTGNP
CBL
0.9786
More...
