DegronMD

Uniprot ID: P26367

Source protein: Paired box protein Pax-6

Source gene: PAX6

Class: CBL_PTK

Location: 324:330

E3 ligase: CBL

DEGRON score: 0.6923

ASA_SCORE: 39.4571

COIL: 0.8601

CONS_SCORE: 0.5637

DSS_SCORE: 0.4714

HELIX: 0.0597

FCONS_SCORE: 1.1553

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T317I	TCGA-69-7979	LUAD	TCGA	NTYSALP	CBL_PTK	0.1389
p.T332A	TCGA-EE-A2M5	SKCM	TCGA	NTYSALP	CBL_PTK	0.2778
p.S322F	TCGA-EE-A2MK	SKCM	TCGA	NTYSALP	CBL_PTK	0.2778
p.P330L	DO7962	COAD	ICGC	NTYSALP	CBL_PTK	0.7582
p.N339D	DO8842	COAD	ICGC	NTYSALP	CBL_PTK	0.0833
p.T318A	DO222423	MELA	ICGC	NTYSALP	CBL_PTK	0.1667
p.T318A	DO37425	SKCM	ICGC	NTYSALP	CBL_PTK	0.1667
p.S327I	DO232224	PBCA	ICGC	NTYSALP	CBL_PTK	0.7341
p.S334G	DO43202	UCEC	ICGC	NTYSALP	CBL_PTK	0.2222
p.A335T	SIDM01146	Gastric Carcinoma	GDSC	NTYSALP	CBL_PTK	0.1944
p.A335T	ACH-000932	Gastric Cancer	CCLE	NTYSALP	CBL_PTK	0.1944
p.A335T	NCI-SNU-1	stomach	COSMIC	NTYSALP	CBL_PTK	0.1944
p.P319L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	NTYSALP	CBL_PTK	0.1944
p.P319L	ACH-001738	Leukemia	CCLE	NTYSALP	CBL_PTK	0.1944
p.P319L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	NTYSALP	CBL_PTK	0.1944
p.A321T	NCI-SNU-1	stomach	COSMIC	NTYSALP	CBL_PTK	0.25
p.T337S	NCI-H2023	lung	COSMIC	NTYSALP	CBL_PTK	0.1389
p.P339Q	CRO-AP3	NS	COSMIC	NTYSALP	CBL_PTK	0.0833
p.Y333D	NCI-H146	lung	COSMIC	NTYSALP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P26367	Paired box protein Pax-6	CBL_PTK	324:330	NTYSALP	CBL	0.6923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons