DegronMD

Uniprot ID: P19484

Source protein: Transcription factor EB

Source gene: TFEB

Class: CBL_PTK

Location: 192:198

E3 ligase: CBL

DEGRON score: 0.88

ASA_SCORE: 55.8571

COIL: 0.7349

CONS_SCORE: 0.6908

DSS_SCORE: 0.351

HELIX: 0.1173

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L204M	TCGA-86-7701	LUAD	TCGA	NVYSSDP	CBL_PTK	0.1667
p.L191M	TCGA-DK-A2I4	BLCA	TCGA	NVYSSDP	CBL_PTK	0.3056
p.L191M	DO465	BLCA	ICGC	NVYSSDP	CBL_PTK	0.3056
p.P198S	TCGA-EE-A2MJ	SKCM	TCGA	NVYSSDP	CBL_PTK	0.6752
p.P198S	DO220877	MELA	ICGC	NVYSSDP	CBL_PTK	0.6752
p.P198S	DO38099	SKCM	ICGC	NVYSSDP	CBL_PTK	0.6752
p.M194I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	NVYSSDP	CBL_PTK	0.7618
p.M194I	NCI-H2342	lung	COSMIC	NVYSSDP	CBL_PTK	0.7618
p.P198A	ACH-000321	Leukemia	CCLE	NVYSSDP	CBL_PTK	0.7503
p.G206S	ACH-000931	Skin Cancer	CCLE	NVYSSDP	CBL_PTK	0.1111
p.G206S	ACH-001024	Skin Cancer	CCLE	NVYSSDP	CBL_PTK	0.1111
p.G206S	CHL-1	skin	COSMIC	NVYSSDP	CBL_PTK	0.1111
p.M203I	Hs766T	pancreas	COSMIC	NVYSSDP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19484	Transcription factor EB	CBL_PTK	192:198	NVYSSDP	CBL	0.88	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons