DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_Kelch_Keap1_1

Location: 590:595

E3 ligase: KEAP1

DEGRON score: 0.9099

ASA_SCORE: 82.7667

COIL: 0.9112

CONS_SCORE: 0.4173

DSS_SCORE: 0.4678

HELIX: 0.044

FCONS_SCORE: 0.9538

RIG_SCORE: 0.643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E583D	TCGA-B5-A11E	UCEC	TCGA	NYSSGE	DEG_Kelch_Keap1_1	0.1389
p.E583D	DO41644	UCEC	ICGC	NYSSGE	DEG_Kelch_Keap1_1	0.1389
p.E595Q	TCGA-DK-AA6P	BLCA	TCGA	NYSSGE	DEG_Kelch_Keap1_1	0.6744
p.E595Q	DO219004	BLCA	ICGC	NYSSGE	DEG_Kelch_Keap1_1	0.6744
p.E583K	DO48457	BLCA	ICGC	NYSSGE	DEG_Kelch_Keap1_1	0.1389
p.Q587H	DO232761	PBCA	ICGC	NYSSGE	DEG_Kelch_Keap1_1	0.25
p.G594C	SIDM00565	Oral Cavity Carcinoma	GDSC	NYSSGE	DEG_Kelch_Keap1_1	0.76
p.G594C	OSC-20	upper_aerodigestive_tract	COSMIC	NYSSGE	DEG_Kelch_Keap1_1	0.76
p.Y591C	SIDM00938	Breast Carcinoma	GDSC	NYSSGE	DEG_Kelch_Keap1_1	0.5976
p.Y591C	SIDM00654	Small Cell Lung Carcinoma	GDSC	NYSSGE	DEG_Kelch_Keap1_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_Kelch_Keap1_1	590:595	NYSSGE	KEAP1	0.9099	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons