DegronMD

Uniprot ID: Q9H2Z4

Source protein: Homeobox protein Nkx-2.4

Source gene: NKX2-4

Class: DEG_SCF_FBW7_2

Location: 304:311

E3 ligase: FBXW7

DEGRON score: 0.8752

ASA_SCORE: 49.225

COIL: 0.8838

CONS_SCORE: 0.5028

DSS_SCORE: 0.8734

HELIX: 0.0593

FCONS_SCORE: 0.9214

RIG_SCORE: 0.561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E314D	DO229272	THCA	ICGC	PAPTPAPE	DEG_SCF_FBW7_2	0.25
p.S318I	DO229275	THCA	ICGC	PAPTPAPE	DEG_SCF_FBW7_2	0.1389
p.P301A	SIDM00643	Non-Cancerous	GDSC	PAPTPAPE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2Z4	Homeobox protein Nkx-2.4	DEG_SCF_FBW7_2	304:311	PAPTPAPE	FBXW7	0.8752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons