DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PAPTPERS
Uniprot ID:
Q8NA92
Source protein:
THAP domain-containing protein 8
Source gene:
THAP8
Class:
DEG_SCF_FBW7_1
Location:
153:160
E3 ligase:
FBXW7
DEGRON score:
0.9762
ASA_SCORE:
100.6
COIL:
0.9365
CONS_SCORE:
0.4905
DSS_SCORE:
0.6612
HELIX:
0.0389
FCONS_SCORE:
1.0471
RIG_SCORE:
0.6399
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A169T
TCGA-UF-A71D
HNSC
TCGA
PAPTPERS
DEG_SCF_FBW7_1
0.0833
p.A144D
DO229041
LICA
ICGC
PAPTPERS
DEG_SCF_FBW7_1
0.0833
p.T156N
SIDM00967
Ovarian Carcinoma
GDSC
PAPTPERS
DEG_SCF_FBW7_1
0.7055
p.R159Q
SIDM00159
Biliary Tract Carcinoma
GDSC
PAPTPERS
DEG_SCF_FBW7_1
0.6218
Drug responses associated with THAP8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PAPTPERS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NA92
THAP domain-containing protein 8
DEG_SCF_FBW7_1
153:160
PAPTPERS
FBXW7
0.9762
More...