DegronMD

Uniprot ID: Q8NA92

Source protein: THAP domain-containing protein 8

Source gene: THAP8

Class: DEG_SCF_FBW7_1

Location: 153:160

E3 ligase: FBXW7

DEGRON score: 0.9762

ASA_SCORE: 100.6

COIL: 0.9365

CONS_SCORE: 0.4905

DSS_SCORE: 0.6612

HELIX: 0.0389

FCONS_SCORE: 1.0471

RIG_SCORE: 0.6399

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T156N	SIDM00967	Ovarian Carcinoma	GDSC	PAPTPERS	DEG_SCF_FBW7_1	0.7055
p.R159Q	SIDM00159	Biliary Tract Carcinoma	GDSC	PAPTPERS	DEG_SCF_FBW7_1	0.6218
p.A169T	TCGA-UF-A71D	HNSC	TCGA	PAPTPERS	DEG_SCF_FBW7_1	0.0833
p.A144D	DO229041	LICA	ICGC	PAPTPERS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA92	THAP domain-containing protein 8	DEG_SCF_FBW7_1	153:160	PAPTPERS	FBXW7	0.9762	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons