DegronMD

Uniprot ID: Q8N531

Source protein: F-box/LRR-repeat protein 6

Source gene: FBXL6

Class: DEG_SCF_FBW7_2

Location: 97:104

E3 ligase: FBXW7

DEGRON score: 0.7841

ASA_SCORE: 91.8

COIL: 0.9581

CONS_SCORE: 0.4088

DSS_SCORE: 0.8096

HELIX: 0.0199

FCONS_SCORE: 1.0541

RIG_SCORE: 0.5639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A96T	DO229224	THCA	ICGC	PAPTPTPE	DEG_SCF_FBW7_2	0.3056
p.P97L	SIDM00773	Non-Cancerous	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.6471
p.P97L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.6471
p.P97L	SIDM00774	Breast Carcinoma	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.6471
p.P97L	SIDM00760	Small Cell Lung Carcinoma	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.6471
p.A109T	SIDM00120	Prostate Carcinoma	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.1944
p.A109T	ACH-000979	Prostate Cancer	CCLE	PAPTPTPE	DEG_SCF_FBW7_2	0.1944
p.A109T	DU-145	prostate	COSMIC	PAPTPTPE	DEG_SCF_FBW7_2	0.1944
p.R114H	SIDM00889	Cervical Carcinoma	GDSC	PAPTPTPE	DEG_SCF_FBW7_2	0.0556
p.R114H	ACH-001333	Cervical Cancer	CCLE	PAPTPTPE	DEG_SCF_FBW7_2	0.0556
p.R114H	C-33-A	cervix	COSMIC	PAPTPTPE	DEG_SCF_FBW7_2	0.0556
p.E105K	ACH-000685	Pancreatic Cancer	CCLE	PAPTPTPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N531	F-box/LRR-repeat protein 6	DEG_SCF_FBW7_2	97:104	PAPTPTPE	FBXW7	0.7841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons