DegronMD

Uniprot ID: Q8N4Y2

Source protein: EF-hand calcium-binding domain-containing protein 4A

Source gene: CRACR2B

Class: DEG_SCF_FBW7_1

Location: 106:113

E3 ligase: FBXW7

DEGRON score: 0.6749

ASA_SCORE: 82.7

COIL: 0.7664

CONS_SCORE: 0.2666

DSS_SCORE: 0.5548

HELIX: 0.1976

FCONS_SCORE: 0.8223

RIG_SCORE: 0.719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G118R	SIDM00680	Colorectal Carcinoma	GDSC	PCRTPEET	DEG_SCF_FBW7_1	0.1944
p.G118R	LS-180	large_intestine	COSMIC	PCRTPEET	DEG_SCF_FBW7_1	0.1944
p.G97A	SIDM00640	Mesothelioma	GDSC	PCRTPEET	DEG_SCF_FBW7_1	0.0833
p.G97A	MSTO-211H	pleura	COSMIC	PCRTPEET	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4Y2	EF-hand calcium-binding domain-containing protein 4A	DEG_SCF_FBW7_1	106:113	PCRTPEET	FBXW7	0.6749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons