DegronMD

Uniprot ID: Q5JPB2

Source protein: Zinc finger protein 831

Source gene: ZNF831

Class: DEG_SCF_FBW7_1

Location: 1330:1337

E3 ligase: FBXW7

DEGRON score: 0.9834

ASA_SCORE: 91.725

COIL: 0.9529

CONS_SCORE: 0.6039

DSS_SCORE: 0.6109

HELIX: 0.0224

FCONS_SCORE: 1.2439

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1334S	TCGA-CM-6164	COAD	TCGA	PCRTPGQT	DEG_SCF_FBW7_1	0.6752
p.P1334S	DO7930	COAD	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.6752
p.P1322L	TCGA-D5-6540	COAD	TCGA	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.P1322L	DO9708	COAD	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.P1322L	DO234328	ESAD	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.P1322L	SIDM00653	Small Cell Lung Carcinoma	GDSC	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.P1322L	ACH-000514	Lung Cancer	CCLE	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.P1322L	NCI-H1092	lung	COSMIC	PCRTPGQT	DEG_SCF_FBW7_1	0.1111
p.G1327R	TCGA-EE-A2GC	SKCM	TCGA	PCRTPGQT	DEG_SCF_FBW7_1	0.25
p.G1327R	DO37839	SKCM	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.25
p.L1344V	TCGA-FJ-A3Z7	BLCA	TCGA	PCRTPGQT	DEG_SCF_FBW7_1	0.1389
p.L1344V	DO463	BLCA	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.1389
p.G1335R	TCGA-W3-AA1V	SKCM	TCGA	PCRTPGQT	DEG_SCF_FBW7_1	0.6457
p.G1335R	DO51276	SKCM	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.6457
p.E1326Q	DO224905	BRCA	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.2222
p.L1325R	DO50411	ESAD	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.1944
p.Q1336H	DO228539	MALY	ICGC	PCRTPGQT	DEG_SCF_FBW7_1	0.647
p.P1334H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PCRTPGQT	DEG_SCF_FBW7_1	0.7694
p.P1334H	ACH-000995	Leukemia	CCLE	PCRTPGQT	DEG_SCF_FBW7_1	0.7694
p.P1334H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PCRTPGQT	DEG_SCF_FBW7_1	0.7694
p.E1326V	SIDM00541	Colorectal Carcinoma	GDSC	PCRTPGQT	DEG_SCF_FBW7_1	0.2222
p.E1326V	HT55	large_intestine	COSMIC	PCRTPGQT	DEG_SCF_FBW7_1	0.2222
p.R1320C	SIDM01619	Endometrial Carcinoma	GDSC	PCRTPGQT	DEG_SCF_FBW7_1	0.0556
p.R1320C	ACH-000984	Endometrial/Uterine Cancer	CCLE	PCRTPGQT	DEG_SCF_FBW7_1	0.0556
p.R1320C	ACH-001610	Brain Cancer	CCLE	PCRTPGQT	DEG_SCF_FBW7_1	0.0556
p.K1329N	ACH-000773	Lymphoma	CCLE	PCRTPGQT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JPB2	Zinc finger protein 831	DEG_SCF_FBW7_1	1330:1337	PCRTPGQT	FBXW7	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PCRTPGQT

Degron related mutations and impact score

Drug responses associated with ZNF831 mutations

All proteins holding degron of PCRTPGQT