DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SCF_FBW7_2

Location: 1492:1498

E3 ligase: FBXW7

DEGRON score: 0.9648

ASA_SCORE: 86.7286

COIL: 0.9281

CONS_SCORE: 0.3244

DSS_SCORE: 0.553

HELIX: 0.024

FCONS_SCORE: 0.9006

RIG_SCORE: 0.6589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1498A	TCGA-BH-A18H	BRCA	TCGA	PCTPAPE	DEG_SCF_FBW7_2	0.7701
p.R1503M	TCGA-G4-6311	COAD	TCGA	PCTPAPE	DEG_SCF_FBW7_2	0.1944
p.A1500D	TCGA-HT-8111	LGG	TCGA	PCTPAPE	DEG_SCF_FBW7_2	0.2778
p.D1484V	DO10332	COAD	ICGC	PCTPAPE	DEG_SCF_FBW7_2	0.1111
p.S1501L	DO14830	HNSC	ICGC	PCTPAPE	DEG_SCF_FBW7_2	0.25
p.V1488L	ACH-000322	Skin Cancer	CCLE	PCTPAPE	DEG_SCF_FBW7_2	0.2222
p.C1493Y	ACH-001610	Brain Cancer	CCLE	PCTPAPE	DEG_SCF_FBW7_2	0.5976
p.S1483N	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCTPAPE	DEG_SCF_FBW7_2	0.0833
p.S1483N	TOV-21G	ovary	COSMIC	PCTPAPE	DEG_SCF_FBW7_2	0.0833
p.G1505E	Sarc9371	bone	COSMIC	PCTPAPE	DEG_SCF_FBW7_2	0.1389
p.G1505R	Sarc9371	bone	COSMIC	PCTPAPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SCF_FBW7_2	1492:1498	PCTPAPE	FBXW7	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons