DegronMD

Uniprot ID: Q96FS4

Source protein: Signal-induced proliferation-associated protein 1

Source gene: SIPA1

Class: DEG_SCF_FBW7_1

Location: 466:472

E3 ligase: FBXW7

DEGRON score: 0.9513

ASA_SCORE: 80.2429

COIL: 0.7793

CONS_SCORE: 0.4043

DSS_SCORE: 0.2462

HELIX: 0.024

FCONS_SCORE: 0.6857

RIG_SCORE: 0.769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R479H	TCGA-A5-A0G2	UCEC	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.1389
p.R479H	DO41235	UCEC	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.1389
p.R462W	TCGA-AX-A2HC	UCEC	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.2222
p.R462W	DO41572	UCEC	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.2222
p.R462L	TCGA-FS-A1ZC	SKCM	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.2222
p.R462L	DO37487	SKCM	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.2222
p.V457A	TCGA-KK-A8I4	PRAD	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.0833
p.V457A	DO219313	PRAD	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.0833
p.A463T	TCGA-SJ-A6ZI	UCEC	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.25
p.A463T	DO219784	UCEC	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.25
p.A463V	TCGA-XK-AAIW	PRAD	TCGA	PCTPHTT	DEG_SCF_FBW7_1	0.25
p.A463V	DO51407	PRAD	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.25
p.V461L	DO228925	LICA	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.1944
p.V477L	DO229031	LICA	ICGC	PCTPHTT	DEG_SCF_FBW7_1	0.1944
p.P466S	SIDM01060	Melanoma	GDSC	PCTPHTT	DEG_SCF_FBW7_1	0.6752
p.P466S	ACH-000882	Skin Cancer	CCLE	PCTPHTT	DEG_SCF_FBW7_1	0.6752
p.P466S	IGR-1	skin	COSMIC	PCTPHTT	DEG_SCF_FBW7_1	0.6752
p.A476T	SIDM00333	Endometrial Carcinoma	GDSC	PCTPHTT	DEG_SCF_FBW7_1	0.2222
p.A476T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PCTPHTT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_SCF_FBW7_1	466:472	PCTPHTT	FBXW7	0.9513	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons