DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_SCF_FBW7_1

Location: 2308:2314

E3 ligase: FBXW7

DEGRON score: 0.8658

ASA_SCORE: 101.0286

COIL: 0.9674

CONS_SCORE: 0.547

DSS_SCORE: 0.8454

HELIX: 0.013

FCONS_SCORE: 0.9887

RIG_SCORE: 0.5871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2323Q	DO234285	ESAD	ICGC	PCTPPDT	DEG_SCF_FBW7_1	0.0833
p.P2299S	DO233737	GACA	ICGC	PCTPPDT	DEG_SCF_FBW7_1	0.0833
p.R2317W	DO222749	MELA	ICGC	PCTPPDT	DEG_SCF_FBW7_1	0.25
p.R2317W	DO33200	PACA	ICGC	PCTPPDT	DEG_SCF_FBW7_1	0.25
p.R2322C	SIDM00683	Prostate Carcinoma	GDSC	PCTPPDT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_SCF_FBW7_1	2308:2314	PCTPPDT	FBXW7	0.8658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons