DegronMD

Uniprot ID: Q5T230

Source protein: Undifferentiated embryonic cell transcription factor 1

Source gene: UTF1

Class: DEG_SCF_FBW7_1

Location: 183:190

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 73.1625

COIL: 0.9116

CONS_SCORE: 0.4915

DSS_SCORE: 0.8428

HELIX: 0.0581

FCONS_SCORE: 1.0539

RIG_SCORE: 0.5971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180L	DO220886	MELA	ICGC	PDATPLPT	DEG_SCF_FBW7_1	0.25
p.T199A	SIDM01608	Endometrial Carcinoma	GDSC	PDATPLPT	DEG_SCF_FBW7_1	0.0833
p.A177V	ACH-000961	Endometrial/Uterine Cancer	CCLE	PDATPLPT	DEG_SCF_FBW7_1	0.1667
p.R194H	ACH-002041	Thyroid Cancer	CCLE	PDATPLPT	DEG_SCF_FBW7_1	0.2222
p.R194H	ACH-002069	Bone Cancer	CCLE	PDATPLPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T230	Undifferentiated embryonic cell transcription factor 1	DEG_SCF_FBW7_1	183:190	PDATPLPT	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons