DegronMD

Uniprot ID: Q9H2C1

Source protein: LIM/homeobox protein Lhx5

Source gene: LHX5

Class: DEG_SCF_FBW7_2

Location: 348:354

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 78.5143

COIL: 0.9663

CONS_SCORE: 0.6622

DSS_SCORE: 0.7608

HELIX: 0.0103

FCONS_SCORE: 1.1011

RIG_SCORE: 0.5494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H347N	DO228985	LICA	ICGC	PDTPSPE	DEG_SCF_FBW7_2	0.3056
p.P358L	DO229211	THCA	ICGC	PDTPSPE	DEG_SCF_FBW7_2	0.2222
p.P358L	ACH-000939	Sarcoma	CCLE	PDTPSPE	DEG_SCF_FBW7_2	0.2222
p.P348L	SIDM02069	Colorectal Carcinoma	GDSC	PDTPSPE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2C1	LIM/homeobox protein Lhx5	DEG_SCF_FBW7_2	348:354	PDTPSPE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons