DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_SCF_FBW7_1

Location: 2289:2296

E3 ligase: FBXW7

DEGRON score: 0.8396

ASA_SCORE: 98.075

COIL: 0.9529

CONS_SCORE: 0.5693

DSS_SCORE: 0.8361

HELIX: 0.0166

FCONS_SCORE: 1.0588

RIG_SCORE: 0.5411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2283E	TCGA-3A-A9J0	PAAD	TCGA	PDWTPHGT	DEG_SCF_FBW7_1	0.1667
p.G2283E	DO218962	PAAD	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.1667
p.T2281I	TCGA-YD-A9TA	SKCM	TCGA	PDWTPHGT	DEG_SCF_FBW7_1	0.1111
p.T2281I	DO219503	SKCM	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.1111
p.R2280W	DO218547	GACA	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.0833
p.P2299S	DO233737	GACA	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.25
p.G2282S	DO228885	MALY	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.1389
p.R2280K	DO222843	MELA	ICGC	PDWTPHGT	DEG_SCF_FBW7_1	0.0833
p.P2293S	SIDM00480	Ovarian Carcinoma	GDSC	PDWTPHGT	DEG_SCF_FBW7_1	0.6752
p.P2293S	ACH-000704	Ovarian Cancer	CCLE	PDWTPHGT	DEG_SCF_FBW7_1	0.6752
p.P2293S	OAW-42	ovary	COSMIC	PDWTPHGT	DEG_SCF_FBW7_1	0.6752
p.G2284C	SIDM00282	Colorectal Carcinoma	GDSC	PDWTPHGT	DEG_SCF_FBW7_1	0.1944
p.G2284C	ACH-000998	Colon/Colorectal Cancer	CCLE	PDWTPHGT	DEG_SCF_FBW7_1	0.1944
p.G2284C	CW-2	large_intestine	COSMIC	PDWTPHGT	DEG_SCF_FBW7_1	0.1944
p.P2292S	OAW-42	ovary	COSMIC	PDWTPHGT	DEG_SCF_FBW7_1	0.6752
p.G2283C	CW-2	large_intestine	COSMIC	PDWTPHGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_SCF_FBW7_1	2289:2296	PDWTPHGT	FBXW7	0.8396	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons